Xuejun Sun

Oct 3, 2024 | biorxiv.org | Yu Zhang |Tianyi Liu |Chuwen Liu |Xuejun Sun

AbstractBackgroundViral respiratory infections are a significant global health burden. Human immune responses to infections caused by respiratory viruses are complex and dependent on the length of time the host has been infected. Human viral challenge studies provide a useful opportunity to understand the timing of human immune responses as samples can be obtained pre-inoculation and post-inoculation by defined virus inocula.

Oct 2, 2024 | biorxiv.org | Xuejun Sun |Yu An Zhang |Chuwen Liu |Xiaojing Zheng

AbstractIntegrated analysis of human gene expression data from multiple studies has become essential in genomics research for complex traits. However, integrating data generated from different cohorts with different platforms, such as microarray and RNA-seq, often requires data preprocessing, including normalization. In this study, we empirically evaluate 9 commonly used cross-platform normalization methods. We classify these methods into two main types: joint and separate normalization.

Oct 10, 2023 | nature.com | Jing Li |Xuejun Sun

AbstractIn the current study, we have shown that USP51 promotes colorectal cancer stemness and chemoresistance, and high expression of USP51 predicts survival disadvantage in colorectal cancer patients. Mechanically, USP51 directly binds to Elongin C (ELOC) and forms a larger functional complex with VHL E3 ligase (USP51/VHL/CUL2/ELOB/ELOC/RBX1) to regulate the ubiquitin-dependent proteasomal degradation of HIF1A.

Aug 9, 2023 | nature.com | Xuejun Sun

AbstractColorectal cancer (CRC) remains a leading cause of cancer-related death worldwide. Cetuximab, in combination with chemotherapy, is effective for treating patients with wild-type KRAS/BRAF metastatic CRC (mCRC). However, intrinsic or acquired drug resistance often limits the use of cetuximab. In this study, we investigated the potential of co-treatment with 3-Bromopyruvate (3-BP) and cetuximab to overcome cetuximab resistance in CRC, both in vitro and in vivo.