Ciaran Sandhu

Apr 24, 2023 | nature.com | Yavuz F. Yazicioglu |Ciaran Sandhu |Barbara Kronsteiner |Moustafa Attar |Susanna J. Dunachie |Michael L. Dustin

AbstractGerminal center (GC) B cells undergo proliferation at very high rates in a hypoxic microenvironment but the cellular processes driving this are incompletely understood. Here we show that the mitochondria of GC B cells are highly dynamic, with significantly upregulated transcription and translation rates associated with the activity of transcription factor A, mitochondrial (TFAM).