Cintia Folgueira

Jan 13, 2025 | nature.com | Beatriz Cicuéndez |Juan Lopez |Juan López |Andrea Curtabbi |Javier Perez-Garcia |Daniel Jimenez-Blasco | +15 more

AbstractObesity poses a global health challenge, demanding a deeper understanding of adipose tissue (AT) and its mitochondria. This study describes the role of the mitochondrial protein Methylation-controlled J protein (MCJ/DnaJC15) in orchestrating brown adipose tissue (BAT) thermogenesis. Here we show how MCJ expression decreases during obesity, as evident in human and mouse adipose tissue samples.

Aug 14, 2024 | science.org | Michael MaY |Michael May |Linru Fang |Sumalata Sonavane |Cintia Folgueira

AbstractSkeletal muscle has gained recognition as an endocrine organ releasing myokines upon contraction during physical exercise. These myokines exert both local and pleiotropic health benefits, underscoring the crucial role of muscle function in countering obesity and contributing to the overall positive effects of exercise on health. Here, we found that exercise activates muscle p38γ, increasing locomotor activity through the secretion of interleukin-15 (IL-15).

Jan 31, 2024 | mdpi.com | Beatriz Cicuéndez |Javier Perez-Garcia |Cintia Folgueira

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