Lauren Reynolds

Nov 9, 2024 | writersdigest.com | Lauren Reynolds

Writing the middle section of a manuscript can be challenging for a variety of reasons. Maintaining story momentum, escalating conflict, and demonstrating character evolution are no easy feat when writing this section. (Alternatives to a Professional Edit.)In fact, writing through the middle can be so challenging that authors, editors, and agents have coined terms for this dastardly phase.

Oct 17, 2024 | nature.com | Lauren Reynolds |Daiana Rigoni |Claire Nguyen |Tinaig Le Borgne |Clara Franco |Fabio Marti | +4 more

AbstractHow nicotine acts on developing neurocircuitry in adolescence to promote later addiction vulnerability remains largely unknown, but may hold the key for informing more effective intervention efforts. We found transient nicotine exposure in early adolescent (PND 21-28) male mice was sufficient to produce a marked vulnerability to nicotine in adulthood (PND 60 + ), associated with disrupted functional connectivity in dopaminergic circuits.

Nov 1, 2023 | biorxiv.org | Lauren Reynolds |Sophie L. Fayad |Aylin Gulmez |Daiana Rigoni

AbstractNicotine use during adolescence is largely associated with negative long-term outcomes, including addiction to nicotine in adulthood. How nicotine acts on developing neurocircuitry in adolescence remains largely unknown, but may hold the key for informing more effective intervention efforts. We found transient nicotine exposure in early adolescence was sufficient for adult mice to show a marked vulnerability to nicotine.

Sep 12, 2023 | frontiersin.org | Leah M Truckenbrod |Emmanuel Darcq |Giovanni Hernández |Lauren Reynolds

1. IntroductionThere are a range of psychiatric disorders that are characterized by forms of altered risk-taking behavior. Although certain disorders, such as eating disorders or generalized anxiety disorder, are characterized by extreme risk aversion, or avoidance of activities that may be associated with potential risk (Lorian and Grisham, 2011; Charpentier et al., 2017; Bernardoni et al., 2020), other psychiatric conditions are associated with increased risk-taking behavior.

Jul 7, 2023 | nature.com | Lauren Reynolds |Santiago Cuesta |Katherine E. Savell |Louis-Eric Trudeau |Jeremy Day |Christina Popescu

AnimalsExperimental procedures were performed according to the guidelines of the Canadian Council of Animal Care and approved by the McGill University/Douglas Mental Health University Institute Animal Care Committee. DATCre or wildtype C57BL/6J mice were bred in the Douglas Mental Health University Institute Neurophenotyping center, or were obtained from Charles River Laboratories (Saint-Constant, QC, Canada).