Claudia Mimoso

Jan 10, 2025 | biorxiv.org | Claudia Mimoso |Hanneke Vlaming |Karen Adelman |Ct Usa

AbstractThe eukaryotic genome is broadly transcribed by RNA polymerase II (RNAPII) to produce protein-coding messenger RNAs (mRNAs) and a repertoire of non-coding RNAs (ncRNAs). Whereas RNAPII is very processive during mRNA transcription, it terminates rapidly during synthesis of many ncRNAs, particularly those that arise opportunistically from accessible chromatin at gene promoters or enhancers.

Nov 2, 2023 | cell.com | Benjamin Martin |Eileen F Ablondi |Christine Goglia |Claudia Mimoso

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Mar 24, 2023 | cell.com | Claudia Mimoso |Karen Adelman

The expansion of introns within mammalian genomes poses a challenge for the production of full-length messenger RNAs (mRNAs), with increasing evidence that these long AT-rich sequences present obstacles to transcription. Here, we investigate RNA polymerase II (RNAPII) elongation at high resolution in mammalian cells and demonstrate that RNAPII transcribes faster across introns.