Hanneke Vlaming

Jan 10, 2025 | biorxiv.org | Claudia Mimoso |Hanneke Vlaming |Karen Adelman |Ct Usa

AbstractThe eukaryotic genome is broadly transcribed by RNA polymerase II (RNAPII) to produce protein-coding messenger RNAs (mRNAs) and a repertoire of non-coding RNAs (ncRNAs). Whereas RNAPII is very processive during mRNA transcription, it terminates rapidly during synthesis of many ncRNAs, particularly those that arise opportunistically from accessible chromatin at gene promoters or enhancers.