Connor A Horton

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Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci - Nature Biotechnology

Feb 20, 2024 | nature.com | Connor A Horton

AbstractCurrent approaches for inserting autonomous transgenes into the genome, such as CRISPR–Cas9 or virus-based strategies, have limitations including low efficiency and high risk of untargeted genome mutagenesis. Here, we describe precise RNA-mediated insertion of transgenes (PRINT), an approach for site-specifically primed reverse transcription that directs transgene synthesis directly into the genome at a multicopy safe-harbor locus.
In Other Journals

Sep 21, 2023 | science.org | Sergiy Kalnaus |Connor A Horton |Jun Cheng |Madeleine Seale |Brad Wible

Plant Science Grafting for successMadeleine SealeGrafting plant roots with the shoots of another plant is common in many agronomic settings. This technique can allow combinations of genotypes with beneficial traits to be combined, for example, by grafting disease-resistant roots with high-yield shoots. However, only certain combinations of species and genotypes are compatible. Thomas et al. examined graft compatibility between four Solanaceae species.
Recovery of walking after paralysis by regenerating characterized neurons to their natural target region

Sep 21, 2023 | science.org | Sergiy Kalnaus |Connor A Horton |Jun Cheng |Jordan W. Squair

Published In ScienceVolume 381 | Issue 666422 September 2023Article versionsSubmission historyReceived: 9 May 2023Accepted: 18 August 2023Published in print: 22 September 2023PermissionsRequest permissions for this article.
Mother Nature’s playground: Sometimes in the wild it is all about fun

Sep 21, 2023 | science.org | Sergiy Kalnaus |Connor A Horton |Jun Cheng |Terrie M. Williams

From surfboard-stealing sea otters to sailboat-chomping killer whales, the summer of 2023 was a landmark year of wild animal antics. Why is wildlife suddenly interacting with humans and their toys in this way? Speculation and headlines have espoused theories about learned behaviors due to enticements with food, increased intrusion, and proximity of humans in wild habitats, as well as aberrant animal responses instigated by oceanic noise or disease-related neurological disorders.
Australia’s path to 30% conservation by 2030

Sep 21, 2023 | science.org | Sergiy Kalnaus |Connor A Horton |Jun Cheng |Ralf C. Buckley

AAAS login provides access to Science for AAAS Members, and access to other journals in the Science family to users who have purchased individual subscriptions. Download and print this article for your personal scholarly, research, and educational use. Buy a single issue of Science for just $15 USD.
In Science Journals

Sep 21, 2023 | science.org | Sergiy Kalnaus |Connor A Horton |Jun Cheng |Bianca Lopez

Research HighlightsMining Impacts Downstream effects of metal minesBianca LopezMining for metals produces waste containing toxic elements such as mercury and arsenic. Macklin et al. compiled global data on the locations of active and inactive metal mines and tailings dams, which hold mine waste. Using hydrologic models, they assessed river system contamination from mines and failed tailings dams and determined the floodplains, people, and livestock that could be affected.
Modeling cartel size to inform violence reduction in Mexico

Sep 21, 2023 | sciencemag.org | Sergiy Kalnaus |Connor A Horton |Jun Cheng |Jonathan P. Caulkins

Immense violence and corruption in Mexico, and their connections to illegal drugs in the United States, are a great problem of our time. Mexico’s homicide rate in 2022 was 25 per 100,000, similar to Colombia’s and more than triple the US rate. Measuring corruption is notoriously difficult, but some Mexican criminal organizations have a history of intimidating and bribing government officials (1). On page 1312 of this issue, Prieto-Curiel et al.