Curtis Cottam

May 25, 2024 | nature.com | Curtis Cottam |Rhys White |Lauren Beck |Christopher Stewart |Scott A. Beatson |Rhys Grinter

AbstractVirulence and metabolism are often interlinked to control the expression of essential colonisation factors in response to host-associated signals. Here, we identified an uncharacterised transporter of the dietary monosaccharide ʟ-arabinose that is widely encoded by the zoonotic pathogen enterohaemorrhagic Escherichia coli (EHEC), required for full competitive fitness in the mouse gut and highly expressed during human infection.

Dec 22, 2023 | biorxiv.org | Rhys White |Lauren Beck |Christopher Stewart |Curtis Cottam

AbstractVirulence and metabolism are often interlinked to control the expression of essential colonisation factors in response to host-associated signals. Here, we identified a novel transporter of the dietary monosaccharide ʟ-arabinose that is widely encoded by the zoonotic pathogen enterohaemorrhagic Escherichia coli (EHEC), required for full competitive fitness in the mouse gut and highly expressed during human infection.