Scott A. Beatson

May 25, 2024 | nature.com | Curtis Cottam |Rhys White |Lauren Beck |Christopher Stewart |Scott A. Beatson |Rhys Grinter

AbstractVirulence and metabolism are often interlinked to control the expression of essential colonisation factors in response to host-associated signals. Here, we identified an uncharacterised transporter of the dietary monosaccharide ʟ-arabinose that is widely encoded by the zoonotic pathogen enterohaemorrhagic Escherichia coli (EHEC), required for full competitive fitness in the mouse gut and highly expressed during human infection.

Mar 12, 2024 | nature.com | Ouli Xie |Jacqueline Morris |Andrew Hayes |Magnus G. Jespersen |John Lees |Sarah L. Baines | +8 more

AbstractStreptococcus dysgalactiae subsp. equisimilis (SDSE) is an emerging cause of human infection with invasive disease incidence and clinical manifestations comparable to the closely related species, Streptococcus pyogenes. Through systematic genomic analyses of 501 disseminated SDSE strains, we demonstrate extensive overlap between the genomes of SDSE and S. pyogenes.

Feb 20, 2024 | nature.com | Seung Jae Kim |Minh-Duy Phan |Matthew Sullivan |Katharine M. Irvine |Scott A. Beatson |Matthew Sweet | +4 more

AbstractBacteria adapt to selective pressure in their immediate environment in multiple ways. One mechanism involves the acquisition of independent mutations that disable or modify a key pathway, providing a signature of adaptation via convergent evolution. Extra-intestinal pathogenic Escherichia coli (ExPEC) belonging to sequence type 95 (ST95) represent a global clone frequently associated with severe human infections including acute pyelonephritis, sepsis, and neonatal meningitis.