Lauren Beck

May 25, 2024 | nature.com | Curtis Cottam |Rhys White |Lauren Beck |Christopher Stewart |Scott A. Beatson |Rhys Grinter

AbstractVirulence and metabolism are often interlinked to control the expression of essential colonisation factors in response to host-associated signals. Here, we identified an uncharacterised transporter of the dietary monosaccharide ʟ-arabinose that is widely encoded by the zoonotic pathogen enterohaemorrhagic Escherichia coli (EHEC), required for full competitive fitness in the mouse gut and highly expressed during human infection.

Dec 22, 2023 | biorxiv.org | Rhys White |Lauren Beck |Christopher Stewart |Curtis Cottam

AbstractVirulence and metabolism are often interlinked to control the expression of essential colonisation factors in response to host-associated signals. Here, we identified a novel transporter of the dietary monosaccharide ʟ-arabinose that is widely encoded by the zoonotic pathogen enterohaemorrhagic Escherichia coli (EHEC), required for full competitive fitness in the mouse gut and highly expressed during human infection.

Sep 15, 2023 | thorax.bmj.com | Jason Powell |Steven Powell |Michael Mather |Lauren Beck

Tracheostomy in children is associated with neutrophilic airway inflammation Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Feb 20, 2023 | thorax.bmj.com | Jason Powell |Steven Powell |Michael Mather |Lauren Beck

Long-term tracheostomy cohortWe aimed to evaluate the airway effects of tracheostomy further in a larger cohort of long-term tracheostomised patients. Tracheal aspirates demonstrated a distinct proteome compared with control aspirates (figure 4A,B). A large proportion of the significantly more abundant proteins identified in long-term tracheostomised patients compared with controls related to neutrophil degranulation (figure 4C).