Daniel Diaz

Sep 9, 2024 | biorxiv.org | Brent Allman |Luiz Vieira |Daniel Diaz |Daniel Díaz |Claus O. Wilke

AbstractPredicting the evolutionary patterns of emerging and endemic viruses is key for mitigating their spread in host populations. In particular, it is critical to rapidly identify mutations with the potential for immune escape or increased disease burden (variants of concern). Knowing which circulating mutations are such variants of concern can inform treatment or mitigation strategies such as alternative vaccines or targeted social distancing.

Jul 23, 2024 | nature.com | Daniel Diaz |Daniel Díaz |James M. Loy |Jordan Wells |Andrew D Ellington

AbstractEngineering stabilized proteins is a fundamental challenge in the development of industrial and pharmaceutical biotechnologies. We present Stability Oracle: a structure-based graph-transformer framework that achieves SOTA performance on accurately identifying thermodynamically stabilizing mutations.

Mar 6, 2024 | nature.com | Simon d’Oelsnitz |Daniel Diaz |Daniel Díaz |Daniel Acosta |James M. Loy |Hal S Alper | +1 more

AbstractA major challenge to achieving industry-scale biomanufacturing of therapeutic alkaloids is the slow process of biocatalyst engineering. Amaryllidaceae alkaloids, such as the Alzheimer’s medication galantamine, are complex plant secondary metabolites with recognized therapeutic value. Due to their difficult synthesis they are regularly sourced by extraction and purification from the low-yielding daffodil Narcissus pseudonarcissus.