James M. Loy

Jul 23, 2024 | nature.com | Daniel Diaz |Daniel Díaz |James M. Loy |Jordan Wells |Andrew D Ellington

AbstractEngineering stabilized proteins is a fundamental challenge in the development of industrial and pharmaceutical biotechnologies. We present Stability Oracle: a structure-based graph-transformer framework that achieves SOTA performance on accurately identifying thermodynamically stabilizing mutations.

Jun 18, 2024 | washingtonpost.com | Mike Hayden |James M. Loy |John D. Negroponte |Sean O’Keefe

Democracy Dies in DarknessMike Hayden was director of the CIA from 2006 to 2009 and of the National Security Agency from 1999 to 2005. James Loy was deputy secretary of Homeland Security from 2003 to 2005 and commandant of the U.S. Coast Guard from 1998 to 2002. J. Michael “Mike” McConnell was director of national intelligence from 2007 to 2009 and of the NSA from 1992 to 1996. John Negroponte was deputy secretary of state from 2007 to 2009 and director of national intelligence from 2005 to 2007.

Mar 6, 2024 | nature.com | Simon d’Oelsnitz |Daniel Diaz |Daniel Díaz |Daniel Acosta |James M. Loy |Hal S Alper | +1 more

AbstractA major challenge to achieving industry-scale biomanufacturing of therapeutic alkaloids is the slow process of biocatalyst engineering. Amaryllidaceae alkaloids, such as the Alzheimer’s medication galantamine, are complex plant secondary metabolites with recognized therapeutic value. Due to their difficult synthesis they are regularly sourced by extraction and purification from the low-yielding daffodil Narcissus pseudonarcissus.