Daniel J. McGrail

Oct 2, 2024 | digitalcommons.library.tmc.edu | Daniel J. McGrail |Roger Smith |Bin Feng |Hui Dai

Home > UTHealth > GSBS > Student and Faculty Publications > 1512 Student and Faculty Publications Cell Reports Medicine homologous recombination, DNA damage, BRCA1, BRCA2, RNA binding proteins, breast cancer, hereditary cancer, network biology, PARP inhibitors DOWNLOADS Included in Bioinformatics Commons, Biomedical Informatics Commons, Medical Sciences Commons, Oncology Commons COinS...

Sep 6, 2024 | digitalcommons.library.tmc.edu | Nathaniel Deboever |Nicolas Zhou |Daniel J. McGrail |Katarzyna Tomczak

BACKGROUND: Malignant pleural mesothelioma (MPM) is associated with poor prognosis despite advances in multimodal therapeutic strategies. While patients with resectable disease may benefit from added survival with oncologic resection, patient selection for mesothelioma operations often relies on both objective and subjective evaluation metrics.

Aug 9, 2024 | digitalcommons.library.tmc.edu | Anupam K. Chakravarty |Daniel J. McGrail |Thomas Lozanoski |Brandon Dunn

UNLABELLED: Multicellularity was a watershed development in evolution. However, it also meant that individual cells could escape regulatory mechanisms that restrict proliferation at a severe cost to the organism: cancer. From the standpoint of cellular organization, evolutionary complexity scales to organize different molecules within the intracellular milieu.

Jan 1, 2024 | nature.com | Jiakai Hou |Yanjun Wei |Long Sun |Shaoheng Liang |Ashley Guerrero |Xiaobo Mao | +7 more

AbstractHost anti-viral factors are essential for controlling SARS-CoV-2 infection but remain largely unknown due to the biases of previous large-scale studies toward pro-viral host factors. To fill in this knowledge gap, we perform a genome-wide CRISPR dropout screen and integrate analyses of the multi-omics data of the CRISPR screen, genome-wide association studies, single-cell RNA-Seq, and host-virus proteins or protein/RNA interactome.

Oct 30, 2023 | cell.com | Daniel J. McGrail |Precision Immuno-Oncology |Roger Smith

Highlights•Aberrations in known HR genes account for a small fraction of HR-deficient tumors•Integrated analysis identifies RNA-binding proteins as a driver of HR deficiency•RBP dysfunction can induce HR deficiency directly or via regulating HR repair genesSummaryDefects in homologous recombination DNA repair (HRD) both predispose to cancer development and produce therapeutic vulnerabilities, making it critical to define the spectrum of genetic events that cause HRD.