Daved H. Fremont

2 months ago | cell.com | Saravanan Raju |Sathvik Palakurty |Alan Sariol |Ngan Wagoner |Lucas Adams |Sean Hui | +3 more

Keywords alphavirus receptor structure pathogenesis therapy cryoelectron microscopy Introduction Alphaviruses are arthropod-transmitted viruses that infect many vertebrate hosts.1 The encephalitic alphaviruses, including Eastern equine encephalitic virus (EEEV), Venezuelan equine encephalitic virus (VEEV), and Western equine encephalitic virus (WEEV), are neurotropic in both horses and humans and cause lethality or long-term neurological sequelae.2 Whereas some bird species serve as enzootic...

Jan 3, 2024 | nature.com | Hongming Ma |Lucas Adams |Daved H. Fremont

AbstractMembers of the low-density lipoprotein receptor (LDLR) family, including LDLRAD3, VLDLR, and ApoER2, were recently described as entry factors for different alphaviruses. However, based on studies with gene edited cells and knockout mice, blockade or abrogation of these receptors does not fully inhibit alphavirus infection, indicating the existence of additional uncharacterized entry factors.