Daved H. Fremont

Jan 3, 2024 | nature.com | Hongming Ma |Lucas Adams |Daved H. Fremont

AbstractMembers of the low-density lipoprotein receptor (LDLR) family, including LDLRAD3, VLDLR, and ApoER2, were recently described as entry factors for different alphaviruses. However, based on studies with gene edited cells and knockout mice, blockade or abrogation of these receptors does not fully inhibit alphavirus infection, indicating the existence of additional uncharacterized entry factors.