David Haussler

Nov 15, 2024 | nature.com | John Andrews |Kateryna Voitiuk |Alex Spaeth |Albert Wang |Jessica L. Sevetson |Kevin C. Donohue | +8 more

AbstractSeizures are made up of the coordinated activity of networks of neurons, suggesting that control of neurons in the pathologic circuits of epilepsy could allow for control of the disease. Optogenetics has been effective at stopping seizure-like activity in non-human disease models by increasing inhibitory tone or decreasing excitation, although this effect has not been shown in human brain tissue.

Feb 6, 2024 | biorxiv.org | Alex Spaeth |David Haussler |Mircea Teodorescu

AbstractDue to the complexity of neuronal networks and the nonlinear dynamics of individual neurons, it is challenging to develop a systems-level model which is accurate enough to be useful yet tractable enough to apply. Mean-field models which extrapolate from single-neuron descriptions to large-scale models can be derived from the neuron's transfer function, which gives its firing rate as a function of its synaptic input.

May 10, 2023 | universityofcalifornia.edu | David Haussler

UC Santa Cruz scientists, along with a consortium of researchers, have released a draft of the first human pangenome — a new, usable reference for genomics that combines the genetic material of 47 individuals from different ancestral backgrounds to allow for a deeper, more accurate understanding of worldwide genomic diversity.