Mircea Teodorescu

Nov 15, 2024 | nature.com | John Andrews |Kateryna Voitiuk |Alex Spaeth |Albert Wang |Jessica L. Sevetson |Kevin C. Donohue | +8 more

AbstractSeizures are made up of the coordinated activity of networks of neurons, suggesting that control of neurons in the pathologic circuits of epilepsy could allow for control of the disease. Optogenetics has been effective at stopping seizure-like activity in non-human disease models by increasing inhibitory tone or decreasing excitation, although this effect has not been shown in human brain tissue.

Sep 13, 2024 | mdpi.com | Anca Vasile |Gianina Dobrescu |Veronica Bratan |Mircea Teodorescu

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Feb 6, 2024 | biorxiv.org | Alex Spaeth |David Haussler |Mircea Teodorescu

AbstractDue to the complexity of neuronal networks and the nonlinear dynamics of individual neurons, it is challenging to develop a systems-level model which is accurate enough to be useful yet tractable enough to apply. Mean-field models which extrapolate from single-neuron descriptions to large-scale models can be derived from the neuron's transfer function, which gives its firing rate as a function of its synaptic input.

Sep 14, 2023 | paperity.org | Pierre V. Baudin |Mircea Teodorescu

PLOS ONE, Sep 2023 For a transparent well with a known volume capacity, changes in fluid level result in predictable changes in magnification of an overhead light source. For a given well size and fluid, the relationship between volume and magnification can be calculated if the fluid’s index of refraction is known or in a naive fashion with a calibration procedure. Light source magnification can be measured through a camera and processed using computer vision contour analysis with OpenCV.

Aug 21, 2023 | mdpi.com | Alex Spaeth |Mircea Teodorescu |Samira Zare |Sandya Suresh

This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticleby 1,*, 1, 2 and 1,* 1Department of Electrical and Computer Engineering, University of California Santa Cruz, Santa Cruz, CA 95064, USA2SIP Program, University of California Santa Cruz, Santa Cruz, CA 95064, USA*Authors to whom correspondence should be addressed.