David Horsfall

Dec 2, 2024 | nature.com | Ruoyan Li |Johanna Strobl |Fereshteh Torabi |Nana-Jane Chipampe |Nina Zila |Nusayhah H. Gopee | +16 more

Correction to: Nature Immunology https://doi.org/10.1038/s41590-024-02018-1, published online 18 November 2024. In the version of the article initially published, the department was incorrect in affiliation 10 which has now been amended to the Division of Dermatology, Department of Medicine, Solna and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden in the HTML and PDF versions of the article.

Nov 18, 2024 | nature.com | Ruoyan Li |Johanna Strobl |Fereshteh Torabi |Nana-Jane Chipampe |Nina Zila |Harriet Johnson | +16 more

AbstractCutaneous T cell lymphoma (CTCL) is a potentially fatal clonal malignancy of T cells primarily affecting the skin. The most common form of CTCL, mycosis fungoides, can be difficult to diagnose, resulting in treatment delay. We performed single-cell and spatial transcriptomics analysis of skin from patients with mycosis fungoides-type CTCL and an integrated comparative analysis with human skin cell atlas datasets from healthy and inflamed skin.

Aug 19, 2024 | nature.com | David Horsfall |Daniela Basurto-Lozada |Kenny Roberts |Martin Prete |Peng He |Josh Moore | +5 more

Multimodal tissue atlasing datasets pose two key challenges for online dissemination and equitable access. First, single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics data objects are often saved in non-unified sequencing and imaging file formats that perform poorly with web technologies. Second, existing software platforms do not readily support simultaneous browsing of multiple integrated data modalities.

Jun 1, 2023 | nature.com | David Horsfall |Neil Chue Hong

Research software engineering is central to data-driven biomedical research, but its role is often undervalued and poorly understood. Biomedical and clinical research have become increasingly data driven. Transforming large amounts of data into new discoveries requires cutting-edge analytical approaches, as well as new infrastructure to provide a foundation upon which algorithmic advances can build.

May 22, 2023 | biorxiv.org | Daniela Basurto-Lozada |Kenny Roberts |Martin Prete |David Horsfall

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