de Waele

Sep 16, 2024 | paperity.org | de Waele

Scientific Reports, Sep 2024 This study aimed to develop a physiologically based pharmacokinetic/pharmacodynamic model (PBPK/PD) of meropenem for critically ill patients. A PBPK model of meropenem in healthy adults was established using PK-Sim software and subsequently extrapolated to critically ill patients based on anatomic and physiological parameters.

Jun 2, 2024 | link.springer.com | de Waele |Hôpital Saint-Louis |Paris Sorbonne Cité

As Presidents of the European Society of Intensive Care Medicine (ESICM), we are privileged to navigate the evolving landscape of intensive care medicine. ESICM has aimed to be a global society representing the intensive care unit (ICU) healthcare professionals (HCPs), enhancing care for patients and families worldwide. We are pleased to highlight our diverse activities and initiatives in pursuit of excellence and support for our members.

Feb 21, 2024 | academic.oup.com | Vrije Universiteit Brussel |de Waele

Intestinal failure-associated liver disease (IFALD) is a relatively common complication in individuals receiving parenteral nutrition (PN). IFALD can be manifested as different types of liver injury, including steatosis, cholestasis and fibrosis, and could result in liver failure in some cases. The onset and progression of IFALD are highly dependent on various patient and PN-related risk factors. Despite still being under investigation, several mechanisms have been proposed.

May 20, 2023 | link.springer.com | de Waele

Selective digestive decontamination (SDD) is a strategy that aims to reduce the risk of hospital-acquired bacterial and yeast infections in critically ill patients by administration of topical, non-absorbable antimicrobials in the oropharynx and stomach, typically a combination of tobramycin, colistin and nystatin given as an oral paste and a gastric suspension, combined with a course of up to 5 days of systemic antibiotics (3rd generation cephalosporins or an alternative) [1].

May 16, 2023 | link.springer.com | de Waele

AbstractAdditive manufacturing processes play a disruptive role in several industrial sectors. Among them, wire arc additive manufacturing (WAAM) is a very promising process for the production of large-scale steel components and structures. As a common characteristic of innovative technologies, this process requires additional research and experimental work in order to understand how its thermal cycles will modify the mechanical and metallurgical properties of the manufactured components.