Delaney Sullivan

Jan 31, 2024 | nature.com | Anja Deutzmann |Delaney Sullivan |Renumathy Dhanasekaran |Wei Li |Angela N. Koehler |Yulin Li

AbstractThe MYC oncogene is often dysregulated in human cancer, including hepatocellular carcinoma (HCC). MYC is considered undruggable to date. Here, we comprehensively identify genes essential for survival of MYChigh but not MYClow cells by a CRISPR/Cas9 genome-wide screen in a MYC-conditional HCC model. Our screen uncovers novel MYC synthetic lethal (MYC-SL) interactions and identifies most MYC-SL genes described previously.

Dec 9, 2023 | biorxiv.org | Delaney Sullivan |Lior Pachter

AbstractNext-generation sequencing libraries are constructed with numerous synthetic constructs such as sequencing adapters, barcodes, and unique molecular identifiers. Such sequences can be essential for interpreting results of sequencing assays, and when they contain information pertinent to an experiment, they must be processed and analyzed. We present a tool called splitcode, that enables flexible and efficient parsing, interpreting, and editing of sequencing reads.