Desmond J. Oathes

Apr 29, 2024 | biologicalpsychiatryjournal.com | Hao Yue Zhu |Xiaoyu Tong |Gregory A. Fonzo |Desmond J. Oathes

Major depressive disorder (MDD) has persisted over an extended period. However, comprehension of MDD remains elusive, particularly concerning the disorder-relevant brain alterations and their association with symptoms. Contrastive learning techniques offer a new avenue for distilling patient-specific variability from background heterogeneity, facilitating the identification of association between functional connectivity and symptom profiles in MDD patients.

Apr 23, 2024 | nature.com | Yvette I Sheline |Desmond J. Oathes

AbstractThe dorsolateral prefrontal cortex (dlPFC) is thought to be a key site in the brain’s cognitive control network, supporting cognitive processes like attention and working memory [1,2,3,4,5,6,7]. There is also evidence that the dlPFC is engaged during anxiety regulation tasks, suggesting that anxiety regulation may be mediated in part by dlPFC activity [8,9,10,11,12,13,14,15]. However, the degree to which these two domains of processing overlap is unclear.

Feb 9, 2024 | nature.com | David R. Roalf |Martijn Figee |Desmond J. Oathes

AbstractAlthough neuroimaging has been widely applied in psychiatry, much of the exuberance in decades past has been tempered by failed replications and a lack of definitive evidence to support the utility of imaging to inform clinical decisions. There are multiple promising ways forward to demonstrate the relevance of neuroimaging for psychiatry at the individual patient level.

Apr 10, 2023 | biologicalpsychiatryjournal.com | Desmond J. Oathes

Combining brain stimulation with brain imaging is a natural pairing that can greatly enhance knowledge of how stimulation engages the brain and how this engagement contributes to therapeutic outcomes. Image guided brain stimulation is a cutting-edge approach showing great promise in improving symptoms. However, these studies do not typically include measures of how brain stimulation engages neural circuits at the individual level or how the brain changes in response to the intervention.