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Jun 5, 2024 | 
mdpi.com | Ugur Aslan |Michelle Feijen |J. Wouter Jukema |Gerlinde M. Mulder
All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.
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Mar 6, 2024 | 
nature.com | Minna K. Karjalainen |Eeva Sliz |Elias Allara |Weihua Zhang |Pekka Jousilahti |Kati Kristiansson | +46 more
AbstractGenome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1,2,3,4,5,6,7. This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases8,9,10,11.
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Mar 5, 2024 | 
mdpi.com | Julie Rutten |J. Wouter Jukema |Hoi W. Wu |Emmelien Aten
All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.
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Feb 18, 2024 | 
medrxiv.org | Vincent Q. Sier |Diana van Heemst |Paul H.A. Quax |J. Wouter Jukema
The authors have declared no competing interest. This work was supported by a Leiden University Medical Centre MD/PhD research grant to V.Q. Sier. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
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Nov 27, 2023 | 
onlinelibrary.wiley.com | Nina Ajmone Marsan |J. Wouter Jukema |Minneke J. Coenraad |Roos A. Groen
Over 50%1 of patients with advanced liver cirrhosis present with cardiac dysfunction due to the dysregulation of the haemodynamic circulation, also known as cirrhotic cardiomyopathy (CCM). In particular, the vasodilatory effects secondary to portal hypertension cause hyperdynamic circulation, resulting in left ventricular (LV) systolic and/or diastolic dysfunction.
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Aug 26, 2023 | 
ahajournals.org | Michael Szarek |J. Wouter Jukema |Deepak L. Bhatt |Esther Reijnders
Background: Lipoprotein(a) is a risk factor for cardiovascular events and modifies the benefit of pcsk9 inhibitors (pcsk9i). Lipoprotein(a) concentration can be measured with immunoassays reporting mass or molar concentration or a reference measurement system employing mass spectrometry. Whether the relationships between lipoprotein(a) concentrations and cardiovascular events in a high-risk cohort differ across lipoprotein(a) methods is unknown.
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Aug 26, 2023 | 
ahajournals.org | Michael Szarek |Esther Reijnders |J. Wouter Jukema |Deepak L. Bhatt
Clinical PerspectiveIn patients with recent acute coronary syndrome, we compared 2 immunoassay-based tests that report mass and molar lipoprotein(a) concentration with a mass spectrometry–based test that reports molar apolipoprotein(a) concentration in relation to major adverse cardiovascular event (MACE) risk and reduction of this risk with the PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor alirocumab.
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Aug 10, 2023 | 
nature.com | Nina Ajmone Marsan |Maria Chiara Meucci |J. Wouter Jukema
AbstractCardiomyopathies and valvular heart diseases are typically considered distinct diagnostic categories with dedicated guidelines for their management. However, the interplay between these conditions is increasingly being recognized and they frequently coexist, as in the paradigmatic examples of dilated cardiomyopathy and hypertrophic cardiomyopathy, which are often complicated by the occurrence of mitral regurgitation.
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Aug 2, 2023 | 
nature.com | Yanick Hagemeijer |Albert Smith |Claudia Schurmann |Jennifer Brody |Gardar Sveinbjornsson |Cécile Lecoeur | +82 more
Method detailsPopulationsThe full RHR meta-analysis included 100 studies with data on RHR in up to 835,465 individuals. RHR was obtained from ECG in 54 studies, from pulse rate in 31 studies (of which seven were self-measured by the participants), from blood pressure monitor in nine studies, from electronic medical records in three studies, from manual measurement in one study and through a combination of multiple of the before mentioned methods in two studies.
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Jul 31, 2023 | 
mdpi.com | J. Wouter Jukema |de Graaf |M. Louisa Antoni |Elissa A. S
Open AccessCase ReportbyElissa A. S. Polomski, Michiel A. de Graaf, J. Wouter Jukema and M. Louisa Antoni * Department of Cardiology, Heart Lung Center, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands*Author to whom correspondence should be addressed. J. Cardiovasc. Dev. Dis.
