Diane E. Dickel

Jul 6, 2023 | nature.com | Iros Barozzi |Marco Osterwalder |Susan Mackem |Terence D. Capellini |Diane E. Dickel |Nicoletta Bobola | +5 more

AbstractA lingering question in developmental biology has centered on how transcription factors with widespread distribution in vertebrate embryos can perform tissue-specific functions. Here, using the murine hindlimb as a model, we investigate the elusive mechanisms whereby PBX TALE homeoproteins, viewed primarily as HOX cofactors, attain context-specific developmental roles despite ubiquitous presence in the embryo.

Apr 20, 2023 | nature.com | Sudha Rajderkar |Iros Barozzi |Yiwen Zhu |Ana Alcaina Caro |Matthew Blow |Jennifer A. Akiyama | +3 more

ENCODE ChIP-seq data analysis and prioritization of TAD boundary deletion lociPreviously published chromosome conformation capture data was used for combined analyses and selection of TAD boundary deletion loci in this study, wherein TAD boundary calls were based on the maximum enrichment of CTCF at the TAD borders and their consistency across cell-types10. Over 3300 genome-wide annotated TAD boundaries5,10 were then ranked on a weighted score (see Supplementary Fig.