Nicoletta Bobola

Jul 6, 2023 | nature.com | Iros Barozzi |Marco Osterwalder |Susan Mackem |Terence D. Capellini |Diane E. Dickel |Nicoletta Bobola | +5 more

AbstractA lingering question in developmental biology has centered on how transcription factors with widespread distribution in vertebrate embryos can perform tissue-specific functions. Here, using the murine hindlimb as a model, we investigate the elusive mechanisms whereby PBX TALE homeoproteins, viewed primarily as HOX cofactors, attain context-specific developmental roles despite ubiquitous presence in the embryo.