Djenet Bousbaine

Dec 11, 2024 | nature.com | Inta Gribonika |Verena M. Link |Eduard Ansaldo |Cihan Oguz |Djenet Bousbaine |Michael Fischbach

AbstractThe microbiota colonizes each barrier site and broadly controls host physiology1. However, when uncontrolled, microbial colonists can also promote inflammation and induce systemic infection2. The unique strategies employed at each barrier tissue to control the coexistence of the host with its microbiota remain largely elusive. Here we uncover that, within the skin, host-microbiota symbiosis depends on the remarkable ability of the skin to act as an autonomous lymphoid organ.

Dec 11, 2024 | nature.com | Djenet Bousbaine |Pranav Lalgudi |David Li |Sunit Jain |Martin Mclaughlin |Inta Gribonika | +4 more

AbstractThe ubiquitous skin colonist Staphylococcus epidermidis elicits a CD8+ T cell response pre-emptively, in the absence of an infection1. However, the scope and purpose of this anti-commensal immune program are not well defined, limiting our ability to harness it therapeutically. Here, we show that this colonist also induces a potent, durable, and specific antibody response that is conserved in humans and non-human primates. A series of S.

Apr 13, 2023 | science.org | Goda Snieckute |Camilla Engblom |Y. Erin Chen |Djenet Bousbaine

Engineered skin bacteria induce antitumor T cell responses against melanomaY. Erin Chen https://orcid.org/0000-0001-9452-1402, Djenet Bousbaine https://orcid.org/0000-0003-2683-9544, [...] , Alessandra Veinbachs https://orcid.org/0000-0001-8419-3097, Katayoon Atabakhsh https://orcid.org/0000-0002-3924-8762, [...] , Alex Dimas https://orcid.org/0000-0003-0191-6275, Victor K. Yu https://orcid.org/0000-0001-5284-2232, Aishan Zhao https://orcid.org/0000-0002-9010-7981, Nora J.