Dominik Paquet

Mar 21, 2024 | nature.com | Stephan Müller |Jakob Körbelin |Ali Erturk |Dominik Paquet |Stefan F. Lichtenthaler |Katalin Todorov-Völgyi

AbstractAge-related decline in brain endothelial cell (BEC) function contributes critically to neurological disease. Comprehensive atlases of the BEC transcriptome have become available, but results from proteomic profiling are lacking. To gain insights into endothelial pathways affected by aging, we developed a magnetic-activated cell sorting-based mouse BEC enrichment protocol compatible with proteomics and resolved the profiles of protein abundance changes during aging.