Stefan F. Lichtenthaler

Mar 21, 2024 | nature.com | Stephan Müller |Jakob Körbelin |Ali Erturk |Dominik Paquet |Stefan F. Lichtenthaler |Katalin Todorov-Völgyi

AbstractAge-related decline in brain endothelial cell (BEC) function contributes critically to neurological disease. Comprehensive atlases of the BEC transcriptome have become available, but results from proteomic profiling are lacking. To gain insights into endothelial pathways affected by aging, we developed a magnetic-activated cell sorting-based mouse BEC enrichment protocol compatible with proteomics and resolved the profiles of protein abundance changes during aging.

Aug 18, 2023 | nature.com | Stephan Müller |Stefan F. Lichtenthaler

AbstractPrion-like spreading of protein misfolding is a characteristic of neurodegenerative diseases, but the exact mechanisms of intercellular protein aggregate dissemination remain unresolved. Evidence accumulates that endogenous retroviruses, remnants of viral germline infections that are normally epigenetically silenced, become upregulated in neurodegenerative diseases such as amyotrophic lateral sclerosis and tauopathies.