Dong Lu

Nov 8, 2024 | sciencedirect.com | Kunhao Liu |Gengfeng Zheng |Guo Lin |Dong Lu

Mycotoxins are toxic metabolites produced by molds during their growth and reproduction, which enter the bodies of humans and animals via contaminated food, causing acute or chronic toxicity [1], [2]. Aflatoxin B1 (AFB1), the most toxic mycotoxin, has been classified as the group I potent carcinogen by the World Health Organization, which widely exists in various agricultural products and foods items [3], [4].

Mar 29, 2024 | biorxiv.org | Xin Yu |Dong Lu |Jin Wang

AbstractThe scaffolding function of receptor interacting protein kinase 1 (RIPK1) confers intrinsic and extrinsic resistance to immune checkpoint blockades (ICBs) and has emerged as a promising target for improving cancer immunotherapies. To address the challenge posed by a poorly defined binding pocket within the intermediate domain, we harnessed proteolysis targeting chimera (PROTAC) technology to develop a first-in-class RIPK1 degrader, LD4172.