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Nov 20, 2024 | 
mdpi.com | Xin Yu
1. IntroductionThe parasol (san 傘/繖) originally served as a practical item for providing shade and protection from rain, and after being elaborately decorated, it evolved into a ceremonial canopy. The ceremonial canopy gradually became a device for displaying authority and honoring respected figures. The chuang 幢 can be seen as a multi-layered canopy, with components and construction methods that are quite similar.
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Nov 14, 2024 | 
digitalcommons.library.tmc.edu | Xin Yu |Jin Wang
KeywordsProteolysis, Proteins, Ubiquitin-Protein Ligases, PROTAC, Target Engagement, Nano-BRET, Binding Constant, Relative Intracellular Accumulation CoefficientAbstractIn recent years, Proteolysis Targeting Chimera (PROTAC) technology has emerged as one of the most promising approaches to remove disease-associated proteins by utilizing cells' own destruction machinery.
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Sep 22, 2024 | 
arxiv.org | Hongyu Zhu |Xin Jin |Xin Yu |Mounim A. El-Yacoubi
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Aug 1, 2024 | 
biorxiv.org | Yi Chen |Wei Qian |Daniel Razansky |Xin Yu
AbstractConcurrent recording of EEG/fMRI signals reveals cross-scale neurovascular dynamics that are crucial for elucidating fundamental linkage between function and behaviors. However, MRI scanners generate tremendous artifacts for EEG detection. Despite existing denoising methods, cabled connections to EEG receivers are susceptible to environmental fluctuations inside MRI scanners, creating baseline drifts that complicate EEG signal retrieval from the noisy background.
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Jul 10, 2024 | 
respiratory-research.biomedcentral.com | Xin Yu |Xu Liu |Juan Li |Miao Yu |Minghui Li |Yuliang Xie | +5 more
The method we used is similar to that reported in an earlier study we published [19]. Briefly, the gene expression profiling datasets GSE24988 [20], GSE113439 [21] and GSE117261 [22] are based on GPL6244 ([HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]) were downloaded from the GEO database (https://www.ncbi.nlm.nih.gov/geo/). The GSE24988 dataset contained 62 PH and 22 normal lung tissues. The GSE113439 dataset contained 15 PH and 11 normal lung tissues.
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Jun 21, 2024 | 
scholarship.richmond.edu | Jeffrey Harrison |Xin Yu |Zhou Zhang
Consistency among common measures of corporate social and sustainability performanceDOI10.1016/j.jclepro.2023.136232AbstractThe objective of this study is to thoroughly evaluate and compare three popular databases used in research on the environment, society and governance.
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Jun 11, 2024 | 
journals.plos.org | Xin Yu |Jian Du
Loading metrics Open Access Peer-reviewedResearch Article Citation: Yang Y, Yu X, Du J (2024) The impact of China’s value-added tax credit refunds on enterprise labor demand: Ex-ante analysis and ex-post test. PLoS ONE 19(6): e0305249. https://doi.org/10.1371/journal.pone.0305249Editor: Baogui Xin, Shandong University of Science and Technology, CHINAReceived: November 7, 2023; Accepted: May 27, 2024; Published: June 11, 2024Copyright: © 2024 Yang et al.
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May 14, 2024 | 
nature.com | Yingna Wu |Xin Yu |Na Li |Liang Ding
In this study, we investigate the influence of global innovation networks (GINs) on the innovation output of semiconductor firms. Utilizing negative binomial regression and network analysis, we assess how network positions, specifically degree, betweenness, and closeness centrality, affect firms’ innovation performance, revealing significant positive impacts. Moreover, our results identify a positive U-shaped relationship between structural holes in GINs and innovation performance, suggesting that while moderate network engagement aids innovation, too much can be detrimental. This research provides key insights into optimizing GIN participation for better innovation results in the competitive semiconductor sector.
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Mar 29, 2024 | 
biorxiv.org | Xin Yu |Dong Lu |Jin Wang
AbstractThe scaffolding function of receptor interacting protein kinase 1 (RIPK1) confers intrinsic and extrinsic resistance to immune checkpoint blockades (ICBs) and has emerged as a promising target for improving cancer immunotherapies. To address the challenge posed by a poorly defined binding pocket within the intermediate domain, we harnessed proteolysis targeting chimera (PROTAC) technology to develop a first-in-class RIPK1 degrader, LD4172.
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Jan 18, 2024 | 
pubs.acs.org | Jing Zhou |Xiang Huang |Xin Yu |Liu Yang
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Org. Chem. 2024, XXXX, XXXJing ZhouLaboratory of Asymmetric Synthesis, College of Chemistry and Environmental Engineering, Chongqing University of Arts and Sciences, 319 Honghe Avenue, Yongchuan, Chongqing 402160, P. R. China, Xiang HuangLaboratory of Asymmetric Synthesis, College of Chemistry and Environmental Engineering, Chongqing University of Arts and Sciences, 319 Honghe Avenue, Yongchuan, Chongqing 402160, P. R.
