Duncan Young

Jun 21, 2024 | nature.com | Sebestyén Kamp |Balint Farkas |Jonathan R. Dry |Duncan Young |Ben Sidders |Krishna C. Bulusu | +9 more

Combination therapy is well established as a key intervention strategy for cancer treatment, with the potential to overcome monotherapy resistance and deliver a more durable efficacy. However, given the scale of unexplored potential target space and the resulting combinatorial explosion, identifying efficacious drug combinations is a critical unmet need that is still evolving. In this paper, we demonstrate a network biology-driven, simulation-based solution, the Simulated Cell™. Integration of omics data with a curated signaling network enables the accurate and interpretable prediction of 66,348 combination-cell line pairs obtained from a large-scale combinatorial drug sensitivity screen of 684 combinations across 97 cancer cell lines (BAC = 0.62, AUC = 0.7). We highlight drug combination pairs that interact with DNA Damage Response pathways and are predicted to be synergistic, and deep network insight to identify biomarkers driving combination synergy. We demonstrate that the cancer cell ‘avatars’ capture the biological complexity of their in vitro counterparts, enabling the identification of pathway-level mechanisms of combination benefit to guide clinical translatability.

Oct 24, 2023 | ncl.ac.uk | Stewart S. R. Jamieson |Neil Ross |Fiona J. Clubb |Duncan Young

Published on: 24 October 2023 Scientists at Newcastle University have discovered an ancient landscape that has lain hidden beneath the East Antarctic Ice Sheet for millions of years. The research team, which also involved scientists at Durham University, used satellite data and radio-echo sounding techniques to map a 32,000 km2 area of land underneath the vast ice sheet.

Jul 31, 2023 | thelearningcounsel.com | Duncan Young |Jerry Barone

Editor’s Note: This is the final article of a four-part series on the student mental health crisis and Multi-Tiered Systems of Support (MTSS) for in-school mental health resources. An overview of the MTSS model can be found here. Suicide is now the second leading cause of death for those age 10 to 14. The consequences of rising rates of anxiety and depression among our kids are very real and very serious.

Jul 9, 2023 | thelearningcounsel.com | Duncan Young