
Eilis Hannon
Articles
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Oct 15, 2024 |
nature.com | Emma Dempster |Eilis Hannon |Diego Quattrone |Edoardo Spinazzola |Zhikun Li |Charlotte Gayer-Anderson | +17 more
AbstractThe rising prevalence and legalisation of cannabis worldwide have underscored the need for a comprehensive understanding of its biological impact, particularly on mental health. Epigenetic mechanisms, specifically DNA methylation, have gained increasing recognition as vital factors in the interplay between risk factors and mental health.
Leveraging epigenetic signatures to determine the cell-type of origin from long read sequencing data
Jun 3, 2024 |
biorxiv.org | Eilis Hannon |Jonathan Mill
AbstractDNA methylation differs across tissue- and cell-types with important implications for the analysis of disease-associated differences in tissues such as blood. To uncover the biological processes affected by epigenetic dysregulation, it is essential for epigenetic studies to generate data from the appropriate cell-types. Here we propose a framework to do this computationally from long-read sequencing data, bypassing the need to isolate subtypes of cells experimentally.
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