Jonathan Mill

Oct 15, 2024 | nature.com | Emma Dempster |Eilis Hannon |Diego Quattrone |Edoardo Spinazzola |Zhikun Li |Charlotte Gayer-Anderson | +17 more

AbstractThe rising prevalence and legalisation of cannabis worldwide have underscored the need for a comprehensive understanding of its biological impact, particularly on mental health. Epigenetic mechanisms, specifically DNA methylation, have gained increasing recognition as vital factors in the interplay between risk factors and mental health.

Sep 20, 2024 | nature.com | Shannon L. Risacher |Paula J Bice |Jared Brosch |Kelley Faber |Martin R Farlow |Tatiana Foroud | +29 more

AbstractDetermining the genetic architecture of Alzheimer’s disease pathologies can enhance mechanistic understanding and inform precision medicine strategies. Here, we perform a genome-wide association study of cortical tau quantified by positron emission tomography in 3046 participants from 12 independent studies. The CYP1B1-RMDN2 locus is associated with tau deposition.

Jun 3, 2024 | biorxiv.org | Eilis Hannon |Jonathan Mill

AbstractDNA methylation differs across tissue- and cell-types with important implications for the analysis of disease-associated differences in tissues such as blood. To uncover the biological processes affected by epigenetic dysregulation, it is essential for epigenetic studies to generate data from the appropriate cell-types. Here we propose a framework to do this computationally from long-read sequencing data, bypassing the need to isolate subtypes of cells experimentally.

Jan 24, 2024 | nanoporetech.com | Jonathan Mill

Oxford Nanopore are sponsoring, exhibiting and presenting at this event. The Oxford Nanopore seminar will take place on Wednesday 24th January between 4:40 pm – 5:10 pm GMT. Speaker and presentation details are below. Please register to save your seat at the seminar. Please also visit us at Booth #38 if you are able to attend the event.

Nov 2, 2023 | biologicalpsychiatryjournal.com | Gemma Shireby |Jonathan Mill

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