Eleanor M. Wigmore

2 months ago | nature.com | Valentina Cutano |Eleanor M. Wigmore |Lorna Hopcroft |Stuart Williamson |Cath Eberlein |Simon T. Barry

AbstractLoss of PTEN expression, via homozygous or hemizygous deletion, is common in PIK3CA mutant ER + BC tumors. We assessed reduction of PTEN protein expression on AKT inhibitor capivasertib efficacy in PIK3CA altered tumors. In PIK3CA altered, PTEN protein high models, PI3Kα and AKT inhibition was effective, however ablation and partial PTEN expression reduction attenuated PI3Kαi but not AKTi efficacy, alone or combined with fulvestrant.