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Nov 22, 2024 | 
nature.com | Eleni Maniati |Simon T. Barry |Ranjit Manchanda |Samar Elorbany
AbstractSingle-cell RNA sequencing (scRNAseq) of tumour-infiltrating immune cells in high-grade serous ovarian cancer (HGSOC) omental biopsies reveals potential targets that could enhance response to neo-adjuvant chemotherapy (NACT). Analysis of 64,097 cells identifies NACT-induced overexpression of stabilin-1 (clever-1) on macrophages and FOXP3 in Tregs that is confirmed at the protein level. STAB1 inhibition in vitro induces anti-tumour macrophages.
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Nov 13, 2024 | 
nature.com | Christos Kiourtis |Maria Terradas-Terradas |Stephanie May |Anastasia Georgakopoulou |Amy Collins |Eoin D O’Sullivan | +14 more
AbstractCellular senescence is not only associated with ageing but also impacts physiological and pathological processes, such as embryonic development and wound healing. Factors secreted by senescent cells affect their microenvironment and can induce spreading of senescence locally. Acute severe liver disease is associated with hepatocyte senescence and frequently progresses to multi-organ failure. Why the latter occurs is poorly understood.
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Aug 29, 2024 | 
propertyreporter.co.uk | Simon T. Barry
"Whilst the opportunities relating to the hospitality industry are more limited, they can still be extremely beneficial from an operational perspective, particularly in terms of making more efficient use of external space." If you run or own a hospitality premises with good-sized outdoor spaces, it’s worth considering how you can utilise this space to maximise profits.
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Aug 8, 2024 | 
mdpi.com | Shauna McClelland |Cristina Branco |Simon T. Barry |Pamela J. Maxwell
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Jul 16, 2024 | 
nature.com | Nikita Sushentsev |Daniel Birtles |Stephanie Ling |Mary A McLean |Jodi Miller |Ian Mills | +2 more
AbstractHyperpolarised magnetic resonance imaging (HP-13C-MRI) has shown promise as a clinical tool for detecting and characterising prostate cancer. Here we use a range of spatially resolved histological techniques to identify the biological mechanisms underpinning differential [1-13C]lactate labelling between benign and malignant prostate, as well as in tumours containing cribriform and non-cribriform Gleason pattern 4 disease.
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May 28, 2024 | 
nature.com | Andreas Dannhorn |Lucy Flint |George Poulogiannis |Simon T. Barry |Owen J. Sansom
AbstractThe landscape of tissue-based imaging modalities is constantly and rapidly evolving. While formalin-fixed, paraffin-embedded material is still useful for histological imaging, the fixation process irreversibly changes the molecular composition of the sample. Therefore, many imaging approaches require fresh-frozen material to get meaningful results.
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Feb 27, 2024 | 
science.org | Emily Erickson |Hao Cai |Leslie K. Ferrarelli |Inchul You |Grace Perry |Aurelien Dugourd | +11 more
Research ResourceCANCEREmily C. Erickson https://orcid.org/0000-0003-3494-2605, Inchul You, [...] , Grace Perry https://orcid.org/0000-0002-0404-9237, Aurelien Dugourd https://orcid.org/0000-0002-0714-028X, [...] , Katherine A. Donovan https://orcid.org/0000-0002-8539-5106, Claire Crafter https://orcid.org/0000-0001-6566-0868, Jeffrey W. Johannes https://orcid.org/0000-0001-7242-6682, Stuart Williamson https://orcid.org/0000-0002-5209-4796, Jennifer I.
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Feb 27, 2024 | science.org | Emily Erickson |Hao Cai |Leslie K. Ferrarelli |Inchul You |Grace Perry |Aurelien Dugourd | +11 more
Research ResourceCANCEREmily C. Erickson https://orcid.org/0000-0003-3494-2605, Inchul You, [...] , Grace Perry https://orcid.org/0000-0002-0404-9237, Aurelien Dugourd https://orcid.org/0000-0002-0714-028X, [...] , Katherine A. Donovan https://orcid.org/0000-0002-8539-5106, Claire Crafter https://orcid.org/0000-0001-6566-0868, Jeffrey W. Johannes https://orcid.org/0000-0001-7242-6682, Stuart Williamson https://orcid.org/0000-0002-5209-4796, Jennifer I.
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Feb 23, 2024 | 
propertyreporter.co.uk | Simon T. Barry
"Proposed planning changes would see the introduction of a ‘C5 short-term let use class’ created in England for those short-term lets not used as a sole or main home" - Simon Barry - Boyer On 19 February the Department for Levelling Up, Housing and Communities announced a change in the rules governing Airbnb-type lettings by requiring planning permission for properties let for more than 90 days per year, introducing a mandatory national register of short-term lets and giving councils greater...
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Feb 13, 2024 | 
nature.com | Benjamin Besse |Sylvia Hartl |Patrick M. Forde |Melissa Johnson |Dong-Wan Kim |Boaz E. Aronson | +7 more
AbstractFor patients with non-small-cell lung cancer (NSCLC) tumors without currently targetable molecular alterations, standard-of-care treatment is immunotherapy with anti-PD-(L)1 checkpoint inhibitors, alone or with platinum-doublet therapy. However, not all patients derive durable benefit and resistance to immune checkpoint blockade is common.
