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2 months ago | 
nature.com | Valentina Cutano |Eleanor M. Wigmore |Lorna Hopcroft |Stuart Williamson |Cath Eberlein |Simon T. Barry
AbstractLoss of PTEN expression, via homozygous or hemizygous deletion, is common in PIK3CA mutant ER + BC tumors. We assessed reduction of PTEN protein expression on AKT inhibitor capivasertib efficacy in PIK3CA altered tumors. In PIK3CA altered, PTEN protein high models, PI3Kα and AKT inhibition was effective, however ablation and partial PTEN expression reduction attenuated PI3Kαi but not AKTi efficacy, alone or combined with fulvestrant.
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Dec 1, 2024 | 
managementtoday.co.uk | Stuart Williamson
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Aug 11, 2024 | 
thescottishsun.co.uk | Stuart Williamson |Stuart Patterson |Harry Williamson
FIRE crews have been scrambled to a blaze at a Scots home that was hit by LIGHTNING. Emergency workers were deployed to the scene on Grampian View in Aviemore. Four fire engines and a height appliance were scrambled to the scene. Fortunately, no one was injured in the blaze. A Scottish Fire and Rescue Service spokesperson said: “We were alerted at 10am on Monday, 12 August, to reports of a dwelling fire following a lightning strike on Grampian View, Aviemore.
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May 15, 2024 | 
beva.onlinelibrary.wiley.com | Stuart Williamson
Background Short incomplete sagittal fractures of the proximal phalanx are common in racehorses. Configurations vary; surgical planning has been performed using radiography which has limited ability to differentiate between common configurations. Computed tomographic (CT) imaging accurately maps fracture configuration and may be contributory to case management.
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Feb 27, 2024 | 
science.org | Emily Erickson |Hao Cai |Leslie K. Ferrarelli |Inchul You |Grace Perry |Aurelien Dugourd | +11 more
Research ResourceCANCEREmily C. Erickson https://orcid.org/0000-0003-3494-2605, Inchul You, [...] , Grace Perry https://orcid.org/0000-0002-0404-9237, Aurelien Dugourd https://orcid.org/0000-0002-0714-028X, [...] , Katherine A. Donovan https://orcid.org/0000-0002-8539-5106, Claire Crafter https://orcid.org/0000-0001-6566-0868, Jeffrey W. Johannes https://orcid.org/0000-0001-7242-6682, Stuart Williamson https://orcid.org/0000-0002-5209-4796, Jennifer I.
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Feb 27, 2024 | science.org | Emily Erickson |Hao Cai |Leslie K. Ferrarelli |Inchul You |Grace Perry |Aurelien Dugourd | +11 more
Research ResourceCANCEREmily C. Erickson https://orcid.org/0000-0003-3494-2605, Inchul You, [...] , Grace Perry https://orcid.org/0000-0002-0404-9237, Aurelien Dugourd https://orcid.org/0000-0002-0714-028X, [...] , Katherine A. Donovan https://orcid.org/0000-0002-8539-5106, Claire Crafter https://orcid.org/0000-0001-6566-0868, Jeffrey W. Johannes https://orcid.org/0000-0001-7242-6682, Stuart Williamson https://orcid.org/0000-0002-5209-4796, Jennifer I.
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Feb 23, 2024 | 
nature.com | Stuart Williamson
AbstractTo explore the anti-tumour activity of combining AKT inhibition and docetaxel in PTEN protein null and WT prostate tumours. Mechanisms associated with docetaxel capivasertib treatment activity in prostate cancer were examined using a panel of in vivo tumour models and cell lines. Combining docetaxel and capivasertib had increased activity in PTEN null and WT prostate tumour models in vivo. In vitro short-term docetaxel treatment caused cell cycle arrest in the majority of cells.
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Feb 18, 2024 | 
thegrocer.co.uk | Stuart Williamson
In today’s retail landscape, businesses need to adapt quickly and effectively to survive. Understanding behaviours, needs and expectations has never been more important in winning and retaining customers.
That has been clearly taken on board by Morrisons, which recently announced it will be inviting customers to join management meetings and roundtable discussions. The unorthodox approach sparked questions as to how retailers can truly get closer to customer-centricity.
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Aug 18, 2023 | 
nature.com | Lorna Hopcroft |Stuart Williamson |Susana Ros |Larissa S. Carnevalli |Elza DeBruin
Correction to: npj Breast Cancer https://doi.org/10.1038/s41523-023-00571-w, published online 05 August 2023In this article the author name Scott Hoffmann, was incorrectly written as Scott Hoffman. The original article has been corrected.
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Aug 5, 2023 | 
nature.com | Stuart Williamson |Susana Ros |Lorna Hopcroft |Larissa S. Carnevalli |Elza DeBruin
Cell culture and reagentsAll cell lines were authenticated using DNA fingerprinting short-tandem repeat (STR) assays. To generate resistant cell populations, parental cell lines were exposed to escalating concentrations of palbociclib over 4–6 months. T47D cells were cultured up to a final dose of 3 μM, which generated two PalboR cell pools (named T47D RB− & T47D CDK6H).
