Elena Fernández-Florido

Apr 24, 2023 | nature.com | Elisa Donato |Elisa Espinet |Elisenda Alsina-Sanchis |Elena Fernández-Florido |Andreas Trumpp |Carolin Mogler | +3 more

AbstractPancreatic ductal adenocarcinoma (PDAC) frequently metastasizes into the peritoneum, which contributes to poor prognosis. Metastatic spreading is promoted by cancer cell plasticity, yet its regulation by the microenvironment is incompletely understood. Here, we show that the presence of hyaluronan and proteoglycan link protein-1 (HAPLN1) in the extracellular matrix enhances tumor cell plasticity and PDAC metastasis.