Andreas Trumpp

Jan 3, 2025 | nature.com | Andreas Trumpp

AbstractCirculating tumor cells (CTCs) drive metastasis, the leading cause of death in individuals with breast cancer. Due to their low abundance in the circulation, robust CTC expansion protocols are urgently needed to effectively study disease progression and therapy responses. Here we present the establishment of long-term CTC-derived organoids from female individuals with metastatic breast cancer.

Nov 14, 2024 | cell.com | Zhiyi Chen |Alex Inague |Kamini Kaushal |Gholamreza Fazeli |Tasneem Cheytan |Florencio Porto Freitas | +26 more

Keywordsferroptosiscancer metabolismseleniumselenocysteine metabolismcell deathneuroblastomaIntroductionFerroptosis is a non-apoptotic form of cell death characterized by the iron-dependent accumulation of phospholipid hydroperoxides, ultimately leading to membrane rupture and cell death.1 Due to its association with various pathological conditions, including cancer, neurodegeneration, and tissue damage,2 the mechanisms regulating ferroptosis have garnered increasing interest.

Apr 24, 2023 | nature.com | Elisa Donato |Elisa Espinet |Elisenda Alsina-Sanchis |Elena Fernández-Florido |Andreas Trumpp |Carolin Mogler | +3 more

AbstractPancreatic ductal adenocarcinoma (PDAC) frequently metastasizes into the peritoneum, which contributes to poor prognosis. Metastatic spreading is promoted by cancer cell plasticity, yet its regulation by the microenvironment is incompletely understood. Here, we show that the presence of hyaluronan and proteoglycan link protein-1 (HAPLN1) in the extracellular matrix enhances tumor cell plasticity and PDAC metastasis.