-
Apr 6, 2023 | 
science.org | Giulia Castellani |Ellen Shrock |Chunyou Mao
© 2023 American Association for the Advancement of Science. All rights reserved. AAAS is a partner of HINARI, AGORA, OARE, CHORUS, CLOCKSS, CrossRef and COUNTER. Science ISSN 0036-8075.
-
Apr 6, 2023 | 
science.org | Giulia Castellani |Ellen Shrock |Chunyou Mao
Cryopreserved Primary Human CellsAMSBIO is a leading supplier of cryopreserved primary human cells for research from multiple organs including the lung, liver, intestine, and kidney. Every batch of cells is validated for cell viability, morphology, plating efficiency, and cell marker data. Cells are cultured for 5-7 days before being released and delivered with donor demographics and serology data demonstrating viral and mycoplasma negative status.
-
Apr 6, 2023 | 
science.org | Giulia Castellani |Ellen Shrock |Chunyou Mao
AbstractNon-LTR retrotransposons, or Long Interspersed Nuclear Elements (LINEs), are an abundant class of eukaryotic transposons that insert into genomes by target-primed reverse transcription (TPRT). During TPRT, a target DNA sequence is nicked and primes reverse transcription of the retrotransposon RNA. Here, we report the cryo-electron microscopy structure of the Bombyx mori R2 non-LTR retrotransposon initiating TPRT at its ribosomal DNA target.
-
Apr 6, 2023 | 
science.org | Giulia Castellani |Ellen Shrock |Chunyou Mao |Courtney S. Malo
Cancer Tuning up CAR-T cellsCourtney S. MaloOpen in viewerA major goal for improving chimeric antigen receptor (CAR)–T cell therapy is to ensure that the CAR-T cell products infused into patients with cancer function optimally. However, standard manufacturing protocols do not enrich for cellular phenotypes associated with enhanced function. To address this limitation, Meyran et al. developed a protocol that generates TSTEM-like CAR-T cells that exhibit features of stem-like T cells.
-
Apr 6, 2023 | 
science.org | Giulia Castellani |Ellen Shrock |Chunyou Mao |Nancy M. Haegel
InformationPublished In ScienceVolume 380 | Issue 66407 April 2023CopyrightCopyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Article versionsSubmission historyPublished in print: 7 April 2023PermissionsRequest permissions for this article.
-
Apr 6, 2023 | 
science.org | Giulia Castellani |Ellen Shrock |Chunyou Mao |Jordan W. Squair
Individuals with spinal cord injury (SCI) demonstrate remarkable optimism, despite losing their ability to move, feel, and control many essential bodily functions. Since I started pursuing my MD/PhD in 2015, I have been passionate about the possibility of developing new therapies to improve the lives of people with SCI. I quickly learned that much of the research on SCI focuses on the restoration of movement and sensation.
-
Apr 6, 2023 | 
science.org | Giulia Castellani |Ellen Shrock |Chunyou Mao |Li Zhou
Methyl groups improve a plasticPolyhydroxyalkanoates are a promising class of plastics accessible chemically or microbially from relatively sustainable feedstocks. However, their performance properties lag behind commercial petrochemically derived alternatives. Zhou et al. report that replacing reactive carbonyl-adjacent hydrogens in the monomer with methyl groups produces a polyhydroxyalkanoate that is more robust in multiple respects (see the Perspective by Guillaume).
-
Apr 6, 2023 | 
science.org | Giulia Castellani |Ellen Shrock |Chunyou Mao |Lang Xu
Mobile metal atoms underlying reactionsIn heterogeneous catalysis, it is often assumed that adsorbates have minimal effects on the bonding between surface metal atoms at low temperatures and pressures. Xu et al. used density functional theory to find conditions in which adsorbed molecules can scavenge transition metal atoms by breaking bonds at the surface.
-
Apr 6, 2023 | 
science.org | Giulia Castellani |Ellen Shrock |Chunyou Mao |Peng Guo
(0)eLetters eLetters is a forum for ongoing peer review. eLetters are not edited, proofread, or indexed, but they are screened. eLetters should provide substantive and scholarly commentary on the article. Embedded figures cannot be submitted, and we discourage the use of figures within eLetters in general. If a figure is essential, please include a link to the figure within the text of the eLetter. Please read our Terms of Service before submitting an eLetter. Log In to Submit a Response
