Emanuela Pupo

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TBC1 domain-containing proteins are frequently involved in triple-negative breast cancers in connection with the induction of a glycolytic phenotype - Cell Death & Disease

Sep 3, 2024 | nature.com | Daniele Avanzato |Flavia Martino |Emanuela Pupo |Valentina Audrito |Stefano Freddi |Giovanni Bertalot | +3 more

AbstractMetabolic plasticity is a hallmark of cancer, and metabolic alterations represent a promising therapeutic target. Since cellular metabolism is controlled by membrane traffic at multiple levels, we investigated the involvement of TBC1 domain-containing proteins (TBC1Ds) in the regulation of cancer metabolism. These proteins are characterized by the presence of a RAB-GAP domain, the TBC1 domain, and typically function as attenuators of RABs, the master switches of membrane traffic.

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