Giovanni Bertalot

Jan 14, 2025 | biorxiv.org | Valeria Manara |Giovanni Bertalot |Guglielmo Rambaldelli |Andrea Vutera Cuda

AbstractNOC1, NOC2, and NOC3 are conserved nucleolar proteins essential for regulating ribo-somal RNA (rRNA) maturation, a process critical for cellular homeostasis. NOC1, in Dro-sophila and yeast, enhances nucleolar activity to sustain rRNA processing, whereas its depletion leads to impaired polysome formation, reduced protein synthesis, and apopto-sis. These genes have vertebrate homologs called CEBPZ, NOC2L, and NOC3l.

Sep 3, 2024 | nature.com | Daniele Avanzato |Flavia Martino |Emanuela Pupo |Valentina Audrito |Stefano Freddi |Giovanni Bertalot | +3 more

AbstractMetabolic plasticity is a hallmark of cancer, and metabolic alterations represent a promising therapeutic target. Since cellular metabolism is controlled by membrane traffic at multiple levels, we investigated the involvement of TBC1 domain-containing proteins (TBC1Ds) in the regulation of cancer metabolism. These proteins are characterized by the presence of a RAB-GAP domain, the TBC1 domain, and typically function as attenuators of RABs, the master switches of membrane traffic.

Apr 8, 2024 | mdpi.com | Giulia Boscato Sopetto |Giovanni Bertalot |Roberto Bortolotti |Silvia Casagrande

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Apr 11, 2023 | nature.com | Mattia Forcato |Giovanni Bertalot |Silvio Bicciato

AbstractThe transcription factor ETV7 is an oncoprotein that is up-regulated in all breast cancer (BC) types. We have recently demonstrated that ETV7 promoted breast cancer progression by increasing cancer cell proliferation and stemness and was also involved in the development of chemo- and radio-resistance. However, the roles of ETV7 in breast cancer inflammation have yet to be studied.