Flavia Martino

Sep 3, 2024 | nature.com | Daniele Avanzato |Flavia Martino |Emanuela Pupo |Valentina Audrito |Stefano Freddi |Giovanni Bertalot | +3 more

AbstractMetabolic plasticity is a hallmark of cancer, and metabolic alterations represent a promising therapeutic target. Since cellular metabolism is controlled by membrane traffic at multiple levels, we investigated the involvement of TBC1 domain-containing proteins (TBC1Ds) in the regulation of cancer metabolism. These proteins are characterized by the presence of a RAB-GAP domain, the TBC1 domain, and typically function as attenuators of RABs, the master switches of membrane traffic.

May 17, 2024 | onlinelibrary.wiley.com | Stefano Confalonieri |Rosa Pennisi |Flavia Martino |Bronislava Matoskova

1 Introduction The ability of tumors to adapt their metabolism to match specific needs is a recognized hallmark of cancer, crucial in shaping tumor evolution and disease progression.[1] Metabolic plasticity is exemplified by aerobic glycolysis, commonly referred to as the Warburg effect.[2] This phenomenon involves the avid uptake of glucose by cancer cells and its conversion to lactate even in the presence of oxygen.[3] Traditionally, the Warburg effect was viewed as a strategy adopted by...

May 2, 2023 | gufetto.press | Flavia Martino

Sarà in scena al Teatro Argentina dal 14 marzo al 2 aprile, Uno sguardo dal ponte di Arthur Miller con la traduzione di Masolino D’Amico, regia Massimo Popolizio. Su un palco che diventa un non luogo della memoria, va in scena il dramma di un uomo che, preso in un gorgo confuso e ineluttabile, disegna un cammino dritto e senza scampo verso la sua stessa morte.