Eran Elinav

Dec 2, 2024 | nature.com | Avital Sarusi-Portuguez |Eran Elinav

AbstractIn mucosal barriers, tissue cells and leukocytes collaborate to form specialized niches that support host-microbiome symbiosis. Understanding the spatial organization of these barriers is crucial for elucidating the mechanisms underlying health and disease. The gingiva, a unique mucosal barrier with significant health implications, exhibits intricate tissue architecture and likely contains specialized immunological regions.

May 4, 2024 | nature.com | Amnon Amir |Rotem Hadar |Yadid Algavi |Kathleen Abu-Saad |Thaddeus S. Stappenbeck |Lee A Denson | +4 more

AbstractCrohn disease (CD) burden has increased with globalization/urbanization, and the rapid rise is attributed to environmental changes rather than genetic drift. The Study Of Urban and Rural CD Evolution (SOURCE, n = 380) has considered diet-omics domains simultaneously to detect complex interactions and identify potential beneficial and pathogenic factors linked with rural-urban transition and CD.

Jul 3, 2023 | nature.com | Eran Elinav

AbstractThe intestinal epithelial barrier facilitates homeostatic host–microbiota interactions and immunological tolerance. However, mechanistic dissections of barrier dynamics following luminal stimulation pose a substantial challenge. Here, we describe an ex vivo intestinal permeability assay, X-IPA, for quantitative analysis of gut permeability dynamics at the whole-tissue level.

May 22, 2023 | nature.com | Aaron Javitt |Merav D. Shmueli |Matthias P. Kramer |Aleksandra A. Kolodziejczyk |Kevin Litchfield |Adi Ulman | +7 more

AbstractImmunotherapy revolutionized treatment options in cancer, yet the mechanisms underlying resistance in many patients remain poorly understood. Cellular proteasomes have been implicated in modulating antitumor immunity by regulating antigen processing, antigen presentation, inflammatory signaling and immune cell activation. However, whether and how proteasome complex heterogeneity may affect tumor progression and the response to immunotherapy has not been systematically examined.