Fei Jin

Jan 24, 2025 | biorxiv.org | Juan Du |Wei Lu |Sushant Kumar |Fei Jin

AbstractDetecting noxious heat is vital for survival, triggering pain responses that protect against harm. The TRPM3 channel is a key nociceptor for sensing noxious heat and a promising therapeutic target for pain treatment and neurological disorders such as epilepsy. Here, we functionally and structurally characterized TRPM3 in response to diverse stimuli: the synthetic superagonist CIM0216, the anticonvulsant antagonist primidone, and heat.