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Jan 24, 2025 | 
biorxiv.org | Juan Du |Wei Lu |Sushant Kumar |Fei Jin
AbstractDetecting noxious heat is vital for survival, triggering pain responses that protect against harm. The TRPM3 channel is a key nociceptor for sensing noxious heat and a promising therapeutic target for pain treatment and neurological disorders such as epilepsy. Here, we functionally and structurally characterized TRPM3 in response to diverse stimuli: the synthetic superagonist CIM0216, the anticonvulsant antagonist primidone, and heat.
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Jan 16, 2025 | 
mdpi.com | Juan Du |Yuan Wang |Shaohui Su |Wenwen Wang
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Oct 22, 2024 | 
mdpi.com | Miao-Miao Tian |Gang Liu |Juan Du |Yue Liu
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Sep 30, 2024 | 
mdpi.com | Juan Du |Fan Wu
1. Introduction ∂ t u + u · ∇ u − Δ u + ∇ π = 0 , x ∈ R 3 , t > 0 ∇ · u = 0 , x ∈ R 3 , t > 0 u t = 0 = u 0 ( x ) , x ∈ R 3 , (1) where The Navier–Stokes equation (NSE for short) is one of the fundamental equations of fluid dynamics. The three-dimensional viscous incompressible NSE reads as u = ( u 1 , u 2 , u 3 ) —the velocity field—and π—the pressure—are the unknowns, and u 0 is the initial velocity field.
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Aug 21, 2024 | 
dairyproducer.com | Tanya Eadie |Juan Du
Source: Cornell UniversityBy: Juan DuInbreeding: breeding of genetically closely related individuals (any sort of relative to relative breeding is considered inbreeding).
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Jul 25, 2024 | 
jamanetwork.com | Wanting Qiang |Jia Liu |Jin Liu |Juan Du
Key PointsQuestion
What are the safety, pharmacokinetic, and survival outcomes of B-cell maturation antigen (BCMA)/CD19 dual-targeting chimeric antigen receptor (CAR) T-cell therapy in individuals with high-risk newly diagnosed multiple myeloma who receive it as a frontline treatment? Findings
In this single-arm, open-label phase 1 cohort study including 19 patients in the efficacy analysis, all patients (100%) achieved stringent complete responses and minimal residual disease negativity.
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Jul 18, 2024 | 
resjournals.onlinelibrary.wiley.com | Juan Du
The special issue of Insect Molecular Biology on ‘The role of epigenetics in insects in changing environments’ has arrived. The field of epigenetics is concerned with how different cellular phenotypes arise from the same genotype (Nicoglou & Merlin, 2017). Understanding the nature and operation of epigenetic information is of great contemporary importance and interest (Allis & Jenuwein, 2016; Cavalli & Heard, 2019).
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Jun 21, 2024 | 
dialnet.unirioja.es | Juan Du
IdiomacatalàDeutschEnglishespañoleuskarafrançaisgalegoitalianoportuguêsromână
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May 30, 2024 | 
dovepress.com | Liping Zou |Chunhui Guo |Juan Du |Qing Chen
Back to Journals » Infection and Drug Resistance » Volume 17 Authors Zou L, Kang W, Guo C, Du J, Chen Q, Shi Z, Tang X, Liang L, Tang P, Pan Q, Zhu Q, Yang S, Chang Z, Guo Z, Wu G, Tang S Received 30 May 2024 Accepted for publication 18 August 2024 Published 28 August 2024 Volume 2024:17 Pages 3737—3749 DOI https://doi.org/10.2147/IDR.S467971 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Zhi Ruan Liping...
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May 11, 2024 | 01664-4/abstract&sz=64)
jhltonline.org | Juan Du
Keywords heart failure CH-VAD left ventricular assist device outcomes fully magnetically levitated pump Heart failure presents a major health burden worldwide and is also a pressing issue in China.1 Epidemiological data show that approximately 1.3% of Chinese individuals aged ≥35 years, or an estimated 13.7 million people, suffer from heart failure.2 Within the heart failure population, approximately 10% to 15% will progress to an advanced stage, at which point the prognosis becomes...
