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Jan 20, 2025 | 
arxiv.org | Feng Xu
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Dec 10, 2024 | 
medrxiv.org | Yihan Wu |Feng Xu |Dan Zhu |Anna Li
The authors have declared no competing interest. Grant support from NIH: P41EB031771, R01HL149742, R01AG080104 and R21AG074978. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
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Nov 13, 2024 | 
onlinelibrary.wiley.com | Ying Yang |Feng Xu
Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request.
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Oct 25, 2024 | 
mdpi.com | Weili Guo |Cheng Liu |Feng Xu |Ting Sun
1. IntroductionFrom 2014 to 2022, the European Maritime Safety Agency (EMSA) reported that there was a total of 21,173 maritime accidents, resulting in 6781 injuries and 604 lives lost [1]. Maritime accidents can result in catastrophic damages; thus, the maritime search and rescue (MSAR) operation is significant. In the International Aeronautical and Maritime Search and Rescue (IAMSAR) Manual, the maritime search is identified as one of the most dangerous and complex aspects of MSAR operations [2].
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Oct 7, 2024 | 
lexology.com | Feng Xu
近几年，中国法院受理的专利侵权的诉讼案件数量不断增加。在所有的抗辩事由中，专利无效抗辩无疑是应对专利侵权诉讼的利器。 无效一件专利权，不亚于开展一场激烈的战役，如何结合每件专利权的具体情况，合理利用法律条文之间的有机联系，有层次地、分步骤和有配合地展开抗辩，寻找和攻击专利权的薄弱处，需要专利代理师有很强的专业素养和职业操守。 下面以我公司代理的一件实用新型专利的无效过程，介绍影响无效结果的一些因素，以及专利代理师在无效程序中所发挥的作用。 一、背景介绍...
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Oct 7, 2024 | 
lexology.com | Feng Xu
In recent years, Chinese courts received patent infringement lawsuits have been on a constant rise. Among all the defenses, patent invalidation defense is undoubtedly a powerful tool in dealing with patent infringement allegations and litigations. Invalidating a patent is no less than waging a fierce battle.
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Aug 22, 2024 | 
mdpi.com | Yingying Wang |Feng Xu |Zhe Lin |Jianying Guo
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Jul 25, 2024 | 
preprints.org | Wei Yang |Rui Liu |Feng Xu
PreprintArticleVersion 1This version is not peer-reviewedVersion 1: Received: 24 July 2024 / Approved: 25 July 2024 / Online: 25 July 2024 (13:32:37 CEST)Yang, W.; Liu, R.; Xu, F. Glial-Derived Neurotrophic Factor Improves Impaired Colonic Motility in Mice of Ulcerative Colitis through Connexin 43. Preprints 2024, 2024072059. https://doi.org/10.20944/preprints202407.2059.v1Yang, W.; Liu, R.; Xu, F.
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Jun 11, 2024 | 
mdpi.com | Fan Ye |Xiaobo Li |Nan Zhang |Feng Xu
All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.
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Jun 1, 2024 | 
bmcgeriatr.biomedcentral.com | Yuan Yuan |Yong Yang |Xiaofei Hu |Lin Zhang |Ying Bai |Jiale Zeng | +2 more
Research the dose–response relationship between overall and certain types of exercise and cognitive function in older adults with Alzheimer's disease and dementia. Systemic and Bayesian Model-Based Network Meta-Analysis. In our study, we analyzed data from randomized controlled trials investigating the effects of different exercises on cognitive outcomes in older adults with AD. We searched the Web of Science, PubMed, Cochrane Central Register of Controlled Trials, and Embase up to November 2023. Using the Cochrane Risk of Bias tool (Rob2) for quality assessment and R software with the MBNMA package for data analysis, we determined standard mean differences (SMDs) and 95% confidence intervals (95%CrI) to evaluate exercise's impact on cognitive function in AD. Twenty-seven studies with 2,242 AD patients revealed a nonlinear relationship between exercise and cognitive improvement in AD patients. We observed significant cognitive enhancements at an effective exercise dose of up to 1000 METs-min/week (SMDs: 0.535, SD: 0.269, 95% CrI: 0.023 to 1.092). The optimal dose was found to be 650 METs-min/week (SMDs: 0.691, SD: 0.169, 95% CrI: 0.373 to 1.039), with AE (Aerobic exercise) being particularly effective. For AE, the optimal cognitive enhancement dose was determined to be 660 METs-min/week (SMDs: 0.909, SD: 0.219, 95% CrI: 0.495 to 1.362). Nonlinear dose–response relationship between exercise and cognitive improvement in Alzheimer’s disease, with the optimal AE dose identified at 660 METs-min/week for enhancing cognitive function in AD.
