Feng Yang

Mar 5, 2025 | today.line.me | Fang Dong |Wang Xiuqiong |Gao Zhu |Wang Yaguang |Zhou Qianxian |Huang Zechen | +27 more

* China has set an economic growth target of around 5 percent for 2025, reflecting a sound economic outlook despite increasing global uncertainties. * The government work report outlines an array of other key development goals for this year, including a surveyed urban unemployment rate of around 5.5 percent, over 12 million new urban jobs, and an around 2-percent increase in the consumer price index.

Dec 17, 2024 | mdpi.com | Feng Yang

1. IntroductionWith the continuous evolution of computer vision and deep learning technologies, medical image processing has assumed an increasingly pivotal role in the field of medicine. Medical image registration stands out as a crucial task in this context, involving the alignment and matching of medical images derived from different times, modalities, or positions.

Dec 10, 2024 | nature.com | Kejia Li |Shijie Chen |Keyun Wang |Yan Wang |Yuying Ye |Zheng Fang | +14 more

By using a limited-proteolysis strategy that employs a large amount of trypsin to generate peptides directly from native proteins, we found that ligand-induced protein local stability shifts can be sensitively detected on a proteome-wide scale. This enabled us to develop the peptide-centric local stability assay, a modification-free approach that achieves unprecedented sensitivity in proteome-wide target identification and binding-region determination. We demonstrate the broad applications of the peptide-centric local stability assay by investigating interactions across various biological contexts. The peptide-centric local stability assay (PELSA) can be used to determine ligand-binding targets and binding regions on a proteome-wide scale with high sensitivity.

Nov 2, 2024 | nature.com | Feng Yang

AbstractOsteosarcoma (OS) is a highly aggressive malignant tumor with a high rate of disability and mortality rates, and dysregulated autophagy is a crucial factor in cancer. However, the molecular mechanisms that regulate autophagy in OS remain unclear. This study aimed to explore key molecules that affect autophagy in OS and their regulatory mechanisms.

Oct 10, 2024 | mdpi.com | Feng Yang |Zheng Zhou

1. IntroductionWith the advancement of technology, the structures of experimental factors have become more and more complex. In many experiments, the presence of some factors is determined by the levels of specific factors, where the former factors are called nested factors and the latter factors are called branching factors. The remaining factors, apart from these two kinds, are referred to as shared factors. Here, we revisit the example in [1] to briefly illustrate these three kinds of factors.