Francine E Garrett-Bakelman

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Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight - Nature Communications

Jun 11, 2024 | nature.com | Fei Wu |JangKeun Kim |Cem Meydan |Francine E Garrett-Bakelman |Nazish Sayed |Simon Melov | +4 more

AbstractMicrogravity is associated with immunological dysfunction, though the mechanisms are poorly understood. Here, using single-cell analysis of human peripheral blood mononuclear cells (PBMCs) exposed to short term (25 hours) simulated microgravity, we characterize altered genes and pathways at basal and stimulated states with a Toll-like Receptor-7/8 agonist.

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