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Nov 16, 2024 | 
link.springer.com | Joseph W. Guarnieri |JangKeun Kim |Douglas Wallace |Christopher E. Mason |Masafumi Muratani |Afshin Beheshti
AbstractTo be able to understand how spaceflight can affect human biology, there is a need for maximizing the amount of information that can be obtained from experiments flown to space. Recently there has been an influx of data obtained from astronauts through multi-omics approaches based on both governmental and commercial spaceflight missions. In addition to data from humans, mitochondrial specific data is gathered for other experiments from rodents and other organisms that are flown in space.
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Oct 15, 2024 | 
nature.com | JangKeun Kim |Francisco J. Enguita |Sylvain V Costes |Ryan Scott |Lauren Sanders |David Furman | +3 more
Correction to: Communications Biology https://doi.org/10.1038/s42003-024-06944-6, published online 05 October 2024In the Acknowledgement section, the L.I.G. was supported by the US Army Medical Research Command (award W81XWH2110402) was omitted. The original article has been corrected.
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Oct 4, 2024 | 
nature.com | JangKeun Kim |Francisco J. Enguita |Sylvain V Costes |Ryan Scott |Lauren Sanders |David Furman | +3 more
AbstractIn the era of renewed space exploration, comprehending the effects of the space environment on human health, particularly for deep space missions, is crucial. While extensive research exists on the impacts of spaceflight, there is a gap regarding female reproductive risks. We hypothesize that space stressors could have enduring effects on female health, potentially increasing risks for future pregnancies upon return to Earth, particularly related to small-for-gestational-age (SGA) fetuses.
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Jul 22, 2024 | 
nature.com | Lindsay Rutter |Henry Cope |Nathaniel J. Szewczyk |JangKeun Kim |Eliah G. Overbey |Braden T. Tierney | +4 more
AbstractCommon and rare alleles are now being annotated across millions of human genomes, and omics technologies are increasingly being used to develop health and treatment recommendations. However, these alleles have not yet been systematically characterized relative to aerospace medicine. Here, we review published alleles naturally found in human cohorts that have a likely protective effect, which is linked to decreased cancer risk and improved bone, muscular, and cardiovascular health.
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Jun 11, 2024 | 
nature.com | Henry Cope |Jonas Elsborg |Samuel Demharter |J. McDonald |Chiara Wernecke |Sigrid S. Reinsch | +11 more
AbstractSpaceflight poses a unique set of challenges to humans and the hostile spaceflight environment can induce a wide range of increased health risks, including dermatological issues. The biology driving the frequency of skin issues in astronauts is currently not well understood.
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Jun 11, 2024 | 
nature.com | Fei Wu |JangKeun Kim |Cem Meydan |Francine E Garrett-Bakelman |Nazish Sayed |Simon Melov | +4 more
AbstractMicrogravity is associated with immunological dysfunction, though the mechanisms are poorly understood. Here, using single-cell analysis of human peripheral blood mononuclear cells (PBMCs) exposed to short term (25 hours) simulated microgravity, we characterize altered genes and pathways at basal and stimulated states with a Toll-like Receptor-7/8 agonist.
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Jun 11, 2024 | 
nature.com | Eliah G. Overbey |JangKeun Kim |Braden T. Tierney |Jiwoon Park |Deena Najjar |Remi Klotz | +30 more
AbstractSpaceflight induces molecular, cellular, and physiological shifts in astronauts and poses myriad biomedical challenges to the human body, which are becoming increasingly relevant as more humans venture into space1-6. Yet, current frameworks for aerospace medicine are nascent and lag far behind advancements in precision medicine on Earth, underscoring the need for rapid development of space medicine databases, tools, and protocols.
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Jun 11, 2024 | 
nature.com | Christopher Jones |Eliah G. Overbey |Cem Meydan |Braden T. Tierney |Jiwoon Park |Theodore Nelson | +14 more
AbstractHuman spaceflight has historically been managed by government agencies, such as in the NASA Twins Study1, but new commercial spaceflight opportunities have opened spaceflight to a broader population.
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Jun 11, 2024 | 
nature.com | Christopher Mason |James Green |Jordan Baechle |Mathias Basner |Susan Bailey |Joseph Borg | +34 more
AbstractThe recent acceleration of commercial, private and multi-national spaceflight has created an unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number of crewed missions entering space and preparations for exploration-class (lasting longer than one year) missions. Such rapid advancement into space from many new companies, countries and space-related entities has enabled a ‘second space age’.
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Jun 11, 2024 | 
nature.com | JangKeun Kim |Eliah G. Overbey |Richa Batra |Annalise Schweickart |Deena Najjar |Cem Meydan | +6 more
AbstractAs spaceflight becomes more common with commercial crews, blood-based measures of crew health can guide both astronaut biomedicine and countermeasures. By profiling plasma proteins, metabolites, and extracellular vesicles/particles (EVPs) from the SpaceX Inspiration4 crew, we generated “spaceflight secretome profiles,” which showed significant differences in coagulation, oxidative stress, and brain-enriched proteins.
