Frederick R. Maxfield

Dec 6, 2024 | cell.com | Rudy Jacquet |Fernando González Ibanez |Katherine Picard |Lucy Funes |Gunnar K. Gouras |Marie-Eve Tremblay | +3 more

Keywords Alzheimer’s disease digestive exophagy microglia lysosome amyloid-beta extracellular degradation acid phosphatase electron microscopy 5xFAD lysosomal pH Research topic(s) CP: Neuroscience Introduction Alzheimer’s disease (AD) is a neurodegenerative condition generally associated with the accumulation of large aggregates of amyloid-beta (Aβ) in the brain.1 Microglia, the immune cells of the central nervous system (CNS), maintain brain homeostasis by phagocytosing apoptotic cells,2...

Sep 26, 2024 | biorxiv.org | Cheng-I Jonathan Ma |Weixiang Wang |Frederick R. Maxfield |Noah Steinfeld

AbstractThe recruitment of macrophages to the intima of arteries is considered a critical event in atherosclerotic progression. These macrophages accumulate excessive lipid droplets and become apoptotic foam cells, a hallmark of atherosclerosis. Most studies focus on lipid accumulation through macrophage interaction with modified monomeric LDL. However, in the intima, macrophages predominantly encounter aggregated LDL (agLDL) species.