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2 months ago | 00062-5/abstract?rss=yes&sz=64)
academicradiology.org | Friedrich-Alexander Universität Erlangen-Nürnberg |Universitätsklinikum Erlangen
REFERENCES1. Upadhyaya, A. ∙ Upadhyaya, S.A. ∙ Chang, L. ... Ultrasound‑guided percutaneous radiofrequency and microwave ablation for cervical lymph node metastasis from papillary thyroid carcinoma: a systematic review and meta‑analysis of clinical efficacy and safetyAcad Radiol. 2025; S1076-6332(24)01052-3, Epub ahead of print2. Guang, Y. ∙ Luo, Y. ∙ Zhang, Y. ...
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Oct 30, 2024 | 
academic.oup.com | Friedrich-Alexander Universität Erlangen-Nürnberg
The impact of individual biological/targeted synthetic disease-modifying anti-rheumatic drug (b/tsDMARD) on kidney function in patients with rheumatoid arthritis (RA) remains unclear. This study aimed to determine the comparative effects of b/tsDMARDs on chronic kidney disease (CKD) incidence in patients with RA.
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Jul 22, 2024 | 
academic.oup.com | Friedrich-Alexander-University Erlangen-Nürnberg |Universitätsklinikum Erlangen |Deutsches Zentrum Immuntherapie |Friedrich-Alexander Universität Erlangen-Nürnberg
Hypothesizing that early treatment yields improved prognosis, we aimed to investigate how the timing of immunosuppressive treatment relates to interstitial lung disease (ILD) development and the course of pulmonary function in systemic sclerosis (SSc).
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Feb 15, 2024 | 
trialsjournal.biomedcentral.com | Freiburg im Breisgau |Justus-Liebig-University Gießen |Technische Universität Dresden |Friedrich-Alexander Universität Erlangen-Nürnberg
Clinical trials are the most important method for gaining new insights into the connection between medical treatments, environmental influences, and other factors on people’s health. Furthermore, only randomized controlled trials (RCTs) can provide conclusive evidence for causal effectiveness of new drugs and medical procedures on health. As the main link in the chain of evidence, RCTs are crucial for translating scientific results from basic research to clinical application [1, 2].
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Jan 23, 2024 | 
acrjournals.onlinelibrary.wiley.com | Stefan Siebert |Laura Coates |Georg Schett |Friedrich-Alexander Universität Erlangen-Nürnberg
INTRODUCTION Psoriatic arthritis (PsA) is a chronic, heterogeneous, inflammatory disease with multiple musculoskeletal and dermatologic manifestations.1 Conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) are typically used as first-line treatments for patients with active peripheral arthritis involvement, while biologic DMARDs (bDMARDs) or targeted synthetic DMARDs are often used for those with an inadequate response to csDMARDs. Although advanced therapies, including...
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Jan 18, 2024 | 
arthritis-research.biomedcentral.com | Nordic Bioscience A |Universitätsklinikum Erlangen |Friedrich-Alexander Universität Erlangen-Nürnberg
A supplementary analysis was conducted of baseline, 12 months, and 24 months data from the FNIH Biomarkers Consortium within the OAI. All 600 participants from the FNIH Biomarkers Consortium OA sample were included in this analysis. This is a case–control design study population, which consists of OA progressors (clinical and radiographic progressors combined), clinical-only progressors, radiographic-only progressors, and non-progressors.
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Nov 21, 2023 | 
bmcchem.biomedcentral.com | Universitätsklinikum Erlangen |Friedrich-Alexander Universität Erlangen-Nürnberg
The Cytoscape version of the E2F1 map was downloaded from https://sourceforge.net/projects/e2f1map/files and converted into a format suitable for the Cytoscape plugin NetDS v3.0 [18]. The purpose of this was to identify important nodes and network motifs in the network. The loop length was set to three nodes and feedback motifs (n = 444) were retrieved. We then used the Cytoscape plugin NetworkAnalyzer to evaluate the topological properties of nodes [107].
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Oct 11, 2023 | 
link.aps.org | Friedrich-Alexander Universität Erlangen-Nürnberg |Felix R. Fischer |Michael J. Hartmann |Refik Mansuroglu
Nonequilibrium time evolution of large quantum systems is a strong candidate for quantum advantage. Variational quantum algorithms have been put forward for this task, but their quantum optimization routines suffer from trainability and sampling problems. Here, we present a classical preprocessing routine for variational Hamiltonian simulation that circumvents the need for a quantum optimization by expanding rigorous error bounds in a perturbative regime for suitable time steps.
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Jul 12, 2023 | 
link.springer.com | Friedrich-Alexander Universität Erlangen-Nürnberg
AbstractContextWe report on atomic level of detail analyses of polymer composite models featuring epoxy resin interfaces to silica, iron oxide, and cellulose layers. Using “reactive” molecular dynamics simulations to explore epoxy network formation, resin hardening is investigated in an unprejudiced manner. This allows the detailed characterization of salt-bridges and hydrogen bonds at the interfaces.
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Jul 8, 2023 | 
academic.oup.com | Friedrich-Alexander-University Erlangen-Nürnberg |Universitätsklinikum Erlangen |Deutsches Zentrum Immuntherapie |Friedrich-Alexander Universität Erlangen-Nürnberg
Interstitial lung disease (ILD) is the leading cause of mortality in systemic sclerosis (SSc). Novel biomarkers are crucial to improve outcomes in SSc-ILD. We aimed to compare the performance of potential serum biomarkers of SSc-ILD that reflect different pathogenic processes: KL-6 and SP-D (epithelial injury), CCL18 (type 2 immune response), YKL-40 (endothelial injury and matrix remodelling) and MMP-7 (ECM remodelling).
