Gang Zhang

Nov 1, 2024 | nature.com | Gang Zhang

AbstractQuantum entanglement acts as a crucial part in quantum computation and quantum information, hence quantifying unknown entanglement is an important task. Due to the fact that the amount of entanglement cannot be achieved directly by measuring any physical observables, it remains an open problem to quantify entanglement experimentally. In this work, we provide an effective way to quantify entanglement for the unknown quantum states via artificial neural networks.

Aug 21, 2024 | onlinelibrary.wiley.com | Ning Ren |Germplasm Enhancement |Gang Zhang |Xiaokun Yang

Supporting Information Filename Description pce15095-sup-0001-Supplemental_information_ns.docx21.6 MB Supporting information. REFERENCES , , , , , et al. (2002) MAP kinase signalling cascade in arabidopsis innate immunity. Nature, 415(6875), 977–983. Available from: https://doi.org/10.1038/415977a , , , , , et al.

Jul 15, 2024 | nature.com | Gang Zhang |Hao LI |Bin Wang |Lu Zhou |Lun Fang |Zhongzhe Li | +2 more

Steroid-induced osteonecrosis of the femoral head (SONFH) is the predominant cause of non-traumatic osteonecrosis of the femoral head (ONFH). Impaired blood supply and reduced osteogenic activity of the femoral head are the key pathogenic mechanisms of SONFH. Fibroblast growth factor 23 (FGF23) levels are not only a biomarker for early vascular lesions caused by abnormal mineral metabolism, but can also act directly on the peripheral vascular system, leading to vascular pathology. The aim of this study was to observe the role of FGF23 on bone microarchitecture and vascular endothelium, and to investigate activation of pyroptosis in SONFH. Lipopolysaccharide (LPS) combined with methylprednisolone (MPS) was applied for SONFH mouse models, and adenovirus was used to increase or decrease the level of FGF23. Micro-CT and histopathological staining were used to observe the structure of the femoral head, and immunohistochemical staining was used to observe the vascular density. The cells were further cultured in vitro and placed in a hypoxic environment for 12 h to simulate the microenvironment of vascular injury during SONFH. The effect of FGF23 on osteogenic differentiation was evaluated using alkaline phosphatase staining, alizarin red S staining and expression of bone formation-related proteins. Matrigel tube formation assay in vitro and immunofluorescence were used to detect the ability of FGF23 to affect endothelial cell angiogenesis. Steroids activated the pyroptosis signaling pathway, promoted the secretion of inflammatory factors in SONFH models, led to vascular endothelial dysfunction and damaged the femoral head structure. In addition, FGF23 inhibited the HUVECs angiogenesis and BMSCs osteogenic differentiation. FGF23 silencing attenuated steroid-induced osteonecrosis of the femoral head by inhibiting the pyroptosis signaling pathway, and promoting osteogenic differentiation of BMSCs and angiogenesis of HUVECs in vitro.

May 9, 2024 | mdpi.com | Zebin Li |Lifu Gao |Gang Zhang |Wei Lu

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Nov 19, 2023 | mdpi.com | Shichao Wang |Gang Zhang |Jie Li |Yubo Wang

1. IntroductionThe steel truss girder possesses the advantages of being lightweight, having a long span, and exhibiting high stiffness [1], which makes it widely used in double-deck bridges [2]. Due to factors such as solar radiation, atmospheric temperature [3], wind speed, and other environmental conditions, significant variations occur in its temperature field [4,5], resulting in noticeable temperature discrepancies among components.